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Table 3 Allelic and genotypic frequencies and risks for glioma in Chinese

From: Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case–control study

Genotyped SNPs

 

MAF

Common homozygote (n)

Heterozygote (n)

Rare homozygote (n)

Heterozygote and rare Homozygote (n)

Pfor trend

GPX1 promoter (rs1800668)

Case

0.12

301

66

13

79

 

Control

0.09

314

64

4

68

0.110

OR (95% CI)*

 

Reference

1.05 (0.72-1.53)

3.30 (1.07-10.24)

1.18 (0.82-1.69)

 

CAT 5’region (rs769214)

Case

0.28

198

146

32

178

 

Control

0.29

192

146

36

182

0.609

OR (95% CI)*

 

Reference

0.93 (0.69- 1.26)

0.83 (0.49- 1.39)

0.91 (0.68- 1.21)

 

CAT 5’region (rs7943316)

Case

0.33

180

140

53

193

 

Control

0.29

195

153

32

185

0.074

OR (95% CI)*

 

Reference

1.04 (0.77- 1.41)

1.16 (0.75- 1.79)

1.19 (0.89- 1.58)

 

PON1 3' UTR (rs854552)

Case

0.22

237

120

23

143

 

Control

0.23

231

126

24

150

0.653

OR (95% CI)*

 

Reference

0.96 (0.70- 1.30)

0.96 (0.53- 1.75)

0.96 (0.71- 1.28)

 

PON1 Q192R (rs662)

Case

0.35

161

158

52

210

 

Control

0.36

159

167

52

219

0.833

OR (95% CI)*

 

Reference

0.98 (0.72- 1.34)

1.06 (0.68- 1.65)

1.00 (0.75- 1.33)

 

NQO1 3' UTR (rs10517)

Case

0.39

142

170

60

230

 
 

Control

0.35

154

181

44

225

0.162

 

OR (95% CI)*

 

Reference

0.99 (0.73- 1.35)

1.44 (0.92- 2.26)

1.08 (0.81- 1.45)

 

NQO1 S1P (rs1800566)

Case

0.46

109

181

78

259

 

Control

0.47

108

187

86

273

0.610

OR (95% CI)*

 

Reference

1.00 (0.71- 1.39)

0.93 (0.62- 1.40)

0.98 (0.71- 1.34)

 

MnSOD V16A (rs4880)

Case

0.22

241

107

31

138

 

Control

0.12

293

81

6

87

<0.001

OR (95% CI)*

 

Reference

1.55 (1.11- 2.16)

6.05 (2.48- 14.74)

1.86 (1.35- 2.55)

 

MnSOD 3' UTR (rs5746136)

Case

0.51

95

182

100

282

 

Control

0.46

118

178

85

263

0.058

 

OR (95% CI)*

 

Reference

1.17 (0.83- 1.64)

1.34 (0.90- 1.99)

1.22 (0.89- 1.68)

 

SOD3 T58A (rs2536512)

Case

0.25

235

96

44

140

 

Control

0.11

283

73

25

98

<0.001

OR (95% CI)*

 

Reference

1.51 (1.06- 2.14)

2.01 (1.20- 3.39)

1.64 (1.20- 2.23)

 

SOD3 3' UTR (rs2695232)

Case

0.41

142

165

75

240

 

Control

0.41

134

172

70

242

0.922

OR (95% CI)*

 

Reference

0.87 (0.63- 1.19)

0.97 (0.65- 1.45)

0.90 (0.67- 1.20)

 

NOS1 3' UTR (rs2682826)

Case

0.25

209

104

23

127

 

Control

0.28

193

164

24

188

0.017

OR (95% CI)*

 

Reference

0.57 (0.42- 0.79)

0.87 (0.47- 1.59)

0.61 (0.45- 0.82)

 

NOS1 Q902H (rs1047735)

Case

0.46

123

165

90

255

 

Control

0.49

101

183

94

277

0.197

OR (95% CI)*

 

Reference

0.80 (0.57- 1.11)

0.85 (0.57- 1.25)

0.81 (0.60- 1.11)

 

NOS2 L608S (rs2297518)

Case

0.19

241

120

8

128

 

Control

0.17

255

113

9

122

0.584

OR (95% CI)*

 

Reference

1.10 (0.80- 1.50)

0.92 (0.35- 2.42)

1.08 (0.80- 1.47)

 

NOS2 promoter (rs10459953)

Case

0.40

140

178

64

242

 

Control

0.44

122

184

73

257

0.173

OR (95% CI)*

 

Reference

0.88 (0.64- 1.21)

0.80 (0.53- 1.21)

0.86 (0.64- 1.16)

 

NOS3 D298E (rs1799983)

Case

0.15

282

77

17

94

 

Control

0.12

278

84

15

99

0.856

OR (95% CI)*

 

Reference

0.91 (0.64- 1.29)

1.12 (0.55- 2.29)

0.94 (0.68- 1.30)

 
  1. *Multivariable adjustment by age, gender (male or female), smoking status (never, former or current), and pack-years.
  2. Data in boldface represent P < 0.05.
  3. MAF: Minor Allele frequency.