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Table 3 Allelic and genotypic frequencies and risks for glioma in Chinese

From: Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case–control study

Genotyped SNPs   MAF Common homozygote (n) Heterozygote (n) Rare homozygote (n) Heterozygote and rare Homozygote (n) Pfor trend
GPX1 promoter (rs1800668) Case 0.12 301 66 13 79  
Control 0.09 314 64 4 68 0.110
OR (95% CI)*   Reference 1.05 (0.72-1.53) 3.30 (1.07-10.24) 1.18 (0.82-1.69)  
CAT 5’region (rs769214) Case 0.28 198 146 32 178  
Control 0.29 192 146 36 182 0.609
OR (95% CI)*   Reference 0.93 (0.69- 1.26) 0.83 (0.49- 1.39) 0.91 (0.68- 1.21)  
CAT 5’region (rs7943316) Case 0.33 180 140 53 193  
Control 0.29 195 153 32 185 0.074
OR (95% CI)*   Reference 1.04 (0.77- 1.41) 1.16 (0.75- 1.79) 1.19 (0.89- 1.58)  
PON1 3' UTR (rs854552) Case 0.22 237 120 23 143  
Control 0.23 231 126 24 150 0.653
OR (95% CI)*   Reference 0.96 (0.70- 1.30) 0.96 (0.53- 1.75) 0.96 (0.71- 1.28)  
PON1 Q192R (rs662) Case 0.35 161 158 52 210  
Control 0.36 159 167 52 219 0.833
OR (95% CI)*   Reference 0.98 (0.72- 1.34) 1.06 (0.68- 1.65) 1.00 (0.75- 1.33)  
NQO1 3' UTR (rs10517) Case 0.39 142 170 60 230  
  Control 0.35 154 181 44 225 0.162
  OR (95% CI)*   Reference 0.99 (0.73- 1.35) 1.44 (0.92- 2.26) 1.08 (0.81- 1.45)  
NQO1 S1P (rs1800566) Case 0.46 109 181 78 259  
Control 0.47 108 187 86 273 0.610
OR (95% CI)*   Reference 1.00 (0.71- 1.39) 0.93 (0.62- 1.40) 0.98 (0.71- 1.34)  
MnSOD V16A (rs4880) Case 0.22 241 107 31 138  
Control 0.12 293 81 6 87 <0.001
OR (95% CI)*   Reference 1.55 (1.11- 2.16) 6.05 (2.48- 14.74) 1.86 (1.35- 2.55)  
MnSOD 3' UTR (rs5746136) Case 0.51 95 182 100 282  
Control 0.46 118 178 85 263 0.058
  OR (95% CI)*   Reference 1.17 (0.83- 1.64) 1.34 (0.90- 1.99) 1.22 (0.89- 1.68)  
SOD3 T58A (rs2536512) Case 0.25 235 96 44 140  
Control 0.11 283 73 25 98 <0.001
OR (95% CI)*   Reference 1.51 (1.06- 2.14) 2.01 (1.20- 3.39) 1.64 (1.20- 2.23)  
SOD3 3' UTR (rs2695232) Case 0.41 142 165 75 240  
Control 0.41 134 172 70 242 0.922
OR (95% CI)*   Reference 0.87 (0.63- 1.19) 0.97 (0.65- 1.45) 0.90 (0.67- 1.20)  
NOS1 3' UTR (rs2682826) Case 0.25 209 104 23 127  
Control 0.28 193 164 24 188 0.017
OR (95% CI)*   Reference 0.57 (0.42- 0.79) 0.87 (0.47- 1.59) 0.61 (0.45- 0.82)  
NOS1 Q902H (rs1047735) Case 0.46 123 165 90 255  
Control 0.49 101 183 94 277 0.197
OR (95% CI)*   Reference 0.80 (0.57- 1.11) 0.85 (0.57- 1.25) 0.81 (0.60- 1.11)  
NOS2 L608S (rs2297518) Case 0.19 241 120 8 128  
Control 0.17 255 113 9 122 0.584
OR (95% CI)*   Reference 1.10 (0.80- 1.50) 0.92 (0.35- 2.42) 1.08 (0.80- 1.47)  
NOS2 promoter (rs10459953) Case 0.40 140 178 64 242  
Control 0.44 122 184 73 257 0.173
OR (95% CI)*   Reference 0.88 (0.64- 1.21) 0.80 (0.53- 1.21) 0.86 (0.64- 1.16)  
NOS3 D298E (rs1799983) Case 0.15 282 77 17 94  
Control 0.12 278 84 15 99 0.856
OR (95% CI)*   Reference 0.91 (0.64- 1.29) 1.12 (0.55- 2.29) 0.94 (0.68- 1.30)  
  1. *Multivariable adjustment by age, gender (male or female), smoking status (never, former or current), and pack-years.
  2. Data in boldface represent P < 0.05.
  3. MAF: Minor Allele frequency.