Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case–control study

BMC Cancer

Table 1 Primary information for 16 genotyped SNPs in oxidative pathway genes

Genotyped SNPs	Location/or Amino acid change	MAF for Chinese in database^a	P value for HWE test^b	% Genotyping rate
GPX1: rs1800668 C>T	Promoter	0.078	0.706	99.1
CAT: rs769214 G>A	5’region	0.293	0.275	97.9
CAT: rs7943316 A>T	5’region	0.256	0.822	98.0
PON1: rs854552 T>C	3' UTR	0.179	0.195	99.1
PON1: rs662 G>A	nsSNP/Q192R	0.430	0.424	97.7
NQO1: rs10517 C>T	3' UTR	0.381	0.397	97.7
NQO1: rs1800566 T>C	nsSNP/S1P	0.478	0.757	97.5
MnSOD: rs4880 T>C	nsSNP/V16A	0.146	0.914	98.8
MnSOD: rs5746136 G>A	3' UTR	0.422	0.264	98.7
SOD3: rs2536512 G>A	nsSNP/T58A	0.100	0.730	98.6
SOD3: rs2695232 C>T	3' UTR	0.367	0.284	98.6
NOS1: rs2682826 C>T	3' UTR	0.256	0.163	98.0
NOS1: rs1047735 T>C	nsSNP/Q902H	0.488	0.522	98.4
NOS2: rs2297518 G>A	nsSNP/L608S	0.175	0.426	97.2
NOS2: rs10459953 G>C	Promoter	0.489	0.790	99.1
NOS3: rs1799983 G>T	nsSNP/D298E	0.111	0.586	97.9

Abbreviations: MAF minor allele frequency, HWE Hardy-Weinberg equilibrium.
^aMinor allele frequency in the Chinese (CHB, Han Chinese in Beijing, China) population, as reported in dbSNP database.
^b P values were calculated from our control genotype.

ISSN: 1471-2407