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Table 3 Multivariate survival analysis

From: Epidemiology and outcomes of previously undiagnosed diabetes in older women with breast cancer: an observational cohort study based on SEER-Medicare

 

All-cause mortality

Cancer mortality

Other-cause mortality

 

HR

95% CI

P-Value

HR

95% CI

P-Value

HR

95% CI

P-Value

  

Lower

Upper

  

Lower

Upper

  

Lower

Upper

 

Diabetes status

Previously diagnosed

Reference

Previously undiagnosed

1.13

0.97

1.32

0.11

1.08

0.84

1.40

0.54

1.29

1.02

1.63

0.03

Age at cancer diagnosis (years)

66-70

Reference

71-75

1.12

0.88

1.44

0.35

1.31

0.89

1.92

0.18

0.87

0.57

1.31

0.50

76-80

1.47

1.16

1.85

<0.01

1.37

0.93

2.02

0.11

1.40

0.96

2.02

0.08

>80

1.90

1.53

2.36

<0.0001

1.46

1.02

2.09

0.04

2.16

1.54

3.03

<0.0001

Race/ethnicity

White

Reference

Black

1.08

0.83

1.40

0.58

1.07

0.69

1.66

0.75

0.95

0.61

1.47

0.82

Hispanic

0.86

0.61

1.21

0.37

1.02

0.61

1.72

0.93

1.15

0.69

1.89

0.60

Other

0.92

0.56

1.51

0.74

0.77

0.28

2.08

0.60

1.07

0.53

2.17

0.86

Year of diagnosis

2001

Reference

2002

1.06

0.89

1.27

0.50

1.23

0.89

1.70

0.22

1.20

0.91

1.57

0.19

2003

1.07

0.89

1.29

0.50

1.05

0.75

1.47

0.79

1.09

0.81

1.45

0.58

2004

0.90

0.73

1.10

0.29

1.05

0.73

1.50

0.80

0.90

0.66

1.24

0.53

2005

1.02

0.83

1.25

0.86

1.15

0.81

1.63

0.44

0.95

0.68

1.33

0.75

Estrogen (ER) and progesterone (PR) receptor status

ER or PR positive

Reference

ER and PR positive

0.84

0.70

1.01

0.07

0.64

0.47

0.88

0.01

0.98

0.73

1.31

0.89

ER and PR negative

1.31

1.04

1.64

0.02

1.56

1.10

2.21

0.01

0.90

0.61

1.34

0.61

Unknown/missing

0.86

0.70

1.05

0.14

0.58

0.40

0.83

<0.01

1.06

0.77

1.45

0.74

Histologic grade

1

Reference

2

1.14

0.94

1.39

0.18

2.24

1.42

3.53

<0.01

0.86

0.66

1.12

0.27

3

1.54

1.26

1.88

<0.0001

3.17

2.01

5.01

<0.0001

1.20

0.90

1.59

0.21

4

1.15

0.76

1.72

0.51

3.32

1.65

6.68

<0.01

0.75

0.39

1.46

0.40

Unknown/missing

1.66

1.32

2.08

<0.0001

4.04

2.48

6.57

<0.0001

0.91

0.64

1.28

0.58

NCI Comorbidity Index

0

Reference

1

1.37

1.17

1.61

<0.01

0.99

0.76

1.30

0.96

1.64

1.27

2.12

<0.01

≥ 2

1.83

1.55

2.16

<0.0001

1.11

0.82

1.49

0.51

2.53

1.95

3.27

<0.0001

Indicators of poor performance

0

Reference

≥ 1

1.27

1.10

1.46

<0.01

1.00

0.78

1.28

0.97

1.66

1.33

2.08

<0.0001

Types of physician visits

None

Reference

Primary care and medical specialist

0.56

0.44

0.72

<0.0001

0.44

0.30

0.65

<0.0001

0.61

0.40

0.93

0.02

Primary care, no medical specialist

0.70

0.54

0.92

0.01

0.65

0.43

0.98

0.04

0.63

0.39

1.00

0.05

Medical specialist, no primary care

0.72

0.54

0.96

0.02

0.43

0.26

0.70

<0.01

1.11

0.70

1.75

0.66

Other specialist only

1.02

0.69

1.50

0.94

0.76

0.39

1.46

0.40

1.04

0.55

1.97

0.91

Preventive services

0

Reference

1

0.78

0.63

0.96

0.02

0.78

0.55

1.10

0.15

0.99

0.69

1.42

0.95

≥ 2

0.53

0.43

0.64

<0.0001

0.41

0.29

0.57

<0.0001

0.73

0.52

1.02

0.07

Percent in census tract with some college

<25%

Reference

≥25%

1.09

0.96

1.24

0.20

1.16

0.92

1.46

0.21

1.24

1.01

1.52

0.04

Percent in census tract living in poverty

<5%

Reference

5-7%

0.97

0.80

1.19

0.79

0.94

0.67

1.31

0.72

0.97

0.72

1.30

0.82

8-12%

0.94

0.79

1.12

0.48

0.80

0.59

1.10

0.17

0.92

0.71

1.20

0.55

>12%

1.07

0.90

1.27

0.45

0.93

0.69

1.25

0.61

0.93

0.71

1.22

0.62

Type of geographic area

Large metropolitan

Reference

Metropolitan

0.99

0.86

1.15

0.90

0.80

0.62

1.03

0.09

0.92

0.73

1.15

0.47

Urban

0.97

0.75

1.25

0.80

0.63

0.38

1.06

0.08

0.77

0.49

1.22

0.26

Less urban/rural

0.84

0.67

1.04

0.11

0.60

0.39

0.90

0.01

1.09

0.79

1.51

0.58

  1. HR: Hazard ratio. CI: Confidence interval.