HuR cytoplasmic expression is associated with increased cyclin A expression and poor outcome with upper urinary tract urothelial carcinoma

Table 3 Multivariate analyses of disease-specific, metastasis-free, and urinary bladder recurrence-free survival

Variable	Category	Disease-specific survival			Metastasis-free survival			UB Recurrence-free survival
Variable	Category	Relative risk	95% Confidence interval	pvalue	Relative risk	95% Confidence interval	pvalue	Relative risk	95% Confidence interval	pvalue
Nodal metastasis	Positive vs. negative	5.602	2.912 ~ 10.776	<0.001*	3.174	1.648 ~ 6.115	0.001*	-	-	-
Perineurial invasion	Present vs. absent	3.291	1.522 ~ 7.117	0.002*	2.460	1.120 ~ 5.401	0.025*	-	-	-
Multifocality	Multifocal vs. single	2.816	1.321 ~ 6.004	0.007*	2.408	1.124 ~ 5.158	0.024*	-	-	-
Pattern of invasion	Infiltrative vs. trabecular vs. non-invasive/Nodular	1.596	1.090 ~ 2.337	0.016*	1.307	0.906 ~ 1.885	0.152	-	-	-
Histological grade	High grade vs. low grade	3.751	1.170 ~ 12.024	0.026*	4.187	1.221 ~ 14.364	0.023*	2.113	1.173-3.805	0.013*
HuR Cyto. Exp.^†	High vs. low	1.996	1.039 ~ 3.834	0.038*	1.880	1.074 ~ 3.291	0.027*	1.398	0.886-2.204	0.150
Vascular invasion	Present vs. absent	1.549	0.823 ~ 2.913	0.175	2.872	1.486 ~ 5.550	0.002*	-	-	-
Cyclin A expression	High vs. low	1.632	0.909 ~ 2.932	0.101	1.703	0.994 ~ 2.918	0.053	-	-	-
Primary tumor (T)	T2 ~ T4 vs. Ta ~ T1	1.412	0.586 ~ 3.400	0.442	0.916	0.419 ~ 2.003	0.826	-	-	-
Tumor location	Both renal pelvis and ureter vs. one location alone	0.950	0.614 ~ 1.471	0.819	0.786	0.572 ~ 1.340	0.541	-	-	-
Mitotic rate	≥10 vs. <10/10 hpf	-	-	-	0.849	0.514 ~ 1.402	0.523	-	-	-
Gender	Male vs. female	-	-	-	-	-	-	1.607	1.030-2.507	0.036*

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