Salvage chemoradiotherapy after primary chemotherapy for locally advanced pancreatic cancer: a single-institution retrospective analysis

Table 6 Results of univariate analysis of survival after salvage chemoradiotherapy

Factors	No. of patients	Median survival time (months)	6-month survival (%)	1-year survival (%)	2-year survival (%)	p-value
All patients	30	8.8	77	33	26
Age
< 65	14	8.1	79	29	14
≥ 65	16	9.2	75	38	38	0.2
Gender
Male	16	8.1	75	31	25
Female	14	9.2	79	36	29	0.6
Karnofsky performance status
≥ 80	28	9.1	79	36	28
< 80	2	4.8	50	0	0	0.03
Primary tumor location
Head	15	9.4	93	40	33
Body / tail	15	8.5	60	27	18	0.5
Number of regimens of primary chemotherapy
1	25	9.4	80	40	32
2	5	6.1	60	0	0	0.006
Best response to primary chemotherapy
PR	9	9.2	89	33	33
SD or PD	21	8.5	71	33	24	0.6
Pre-chemoradiotherapy tumor diameter (cm)
≤ 4	12	10.8	83	50	50
> 4	18	8.5	72	22	0	0.04
Pre-chemoradiotherapy serum CA19-9 level (U/ml)
≤ 1,000	29	10.8	90	47	42
> 1,000	11	6.4	54	9	0	0.002
Local progression before starting chemoradiotherapy
Absent	4	NA	80	60	60
Present	26	8.8	76	28	19	0.15
Time from the start of primary chemotherapy to chemoradiotherapy
≤ 6 months	12	8.5	75	33	25
> 6 months	18	8.8	78	33	28	0.9
Combined chemoradiotherapy agents
5-FU	14	7.2	64	21	14
S-1	16	9.9	88	44	37	0.09

PR partial response, SD stable disease, PD progressive disease, NA not available.

ISSN: 1471-2407