Figure 3From: Molecular pathways undergoing dramatic transcriptomic changes during tumor development in the human colon Dysregulation of the cell cycle pathway during tumor progression. Expression levels for the 22 Biocarta cell cycle genes in each tumor stage-specific data subset―SPLs (A), LPLs (B), and CRCs (C)―were compared with those in the normal mucosa (N) data set using two-sample t-test. Each graph contains 22 nodes representing the genes in the pathway (white, yellow, and blue rectangles, and yellow ellipses) plus a node for each tumor-stage being analyzed (green rectangles; those outlined in red represent the stage considered in the panel). Yellow and blue rectangles: genes displaying tumor-associated upregulation or downregulation, respectively, in the stage represented in the panel; white rectangles: genes that were also dysregulated in at least one of the other two stages; yellow ellipses: cell-cycle genes that displayed no tumor-related dysregulation at any of the three stages. The connection matrix used for the graph was a sparse square matrix of order 25 where 1 indicates connection between nodes and 0 indicates no connection. Black lines: connection between a gene node and tumor-stage node (i.e., tumor-related up- or downregulation of the gene at that stage).Back to article page