Stat3 is a positive regulator of gap junctional intercellular communication in cultured, human lung carcinoma cells

Table 2 GJIC in primary lung carcinoma cells ^α

	Cells^β	GJIC^α
Adenosquamous carcinoma, moderately differentiated	carcinoma cells	0.1 ±0.1
	fibroblasts	5.8±1.2
Adenocarcinoma, poorly differentiated	carcinoma cells	0.1 ±0.1
Adenocarcinoma	carcinoma cells	0.1 ±0.1

^αImmediately after surgery, cells were placed in culture and GJIC examined (see Methods, Figure 7). After 8-10 weeks in culture, most of the tumor cells had died while the fibroblasts present in the initial suspension predominated. These cells did not express cytokeratins, contrary to tumor cells [18]. The fibroblasts shown were derived from the moderately differentiated adenosquamous carcinoma tumor above (Figure 3, c-d). GJIC was examined as in Table1, at 3 days after confluence.

ISSN: 1471-2407