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Table 5 Frequency of nausea and vomiting AEs during 1 st cycle of chemotherapy
| Frequency of nausea and vomiting AE (all grade) during 1st cycle of chemotherapy | ||||
|---|---|---|---|---|
| Placebo n = 217 | Cocculine ® n = 214 | All n = 431 | p † | |
| Missing data | 39 | 20 | 59 | |
| Number of patients evaluable | 178 | 194 | 372 | |
| Number of patient with at least 1 AE nausea (%) | 91 (51.1) | 92 (47.4) | 83 (49.2) | 0.48 |
| Missing data | 39 | 20 | 59 | |
| Number of patients evaluable | 178 | 194 | 372 | |
| Number of patient with at least 1 AE vomiting, n (%) | 35 (19.7) | 41 (21.1) | 76 (20.4) | 0.72 |
| Frequency of severe nausea and vomiting AE (Grade ≥ 2) during 1 st cycle of chemotherapy | ||||
| Placebo n = 217 | Cocculine n = 214 | All n = 431 | p † | |
| Missing data | 47 | 29 | 76 | |
| Number of patients evaluable, n | 170 | 185 | 355 | |
| Number of patient with at least 1 severe nausea AE (i.e. Grade ≥2), n (%) | 30 (17.6) | 29 (15.7) | 59 (16.6) | 0.62 |
| Missing data | 41 | 22 | 63 | |
| Number of patients evaluable | 176 | 192 | 368 | |
| Number of patient with at least 1 severe vomiting AE (i.e. Grade ≥ 2), n (%) | 19 (10.8) | 23 (12.0) | 42 (11.4) | 0.72 |
