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Table 5 Frequency of nausea and vomiting AEs during 1 st cycle of chemotherapy

From: Can treatment with Cocculine improve the control of chemotherapy-induced emesis in early breast cancer patients? A randomized, multi-centered, double-blind, placebo-controlled Phase III trial

Frequency of nausea and vomiting AE (all grade) during 1st cycle of chemotherapy
  Placebo n = 217 Cocculine ® n = 214 All n = 431 p
Missing data 39 20 59  
Number of patients evaluable 178 194 372  
Number of patient with at least 1 AE nausea (%) 91 (51.1) 92 (47.4) 83 (49.2) 0.48
Missing data 39 20 59  
Number of patients evaluable 178 194 372  
Number of patient with at least 1 AE vomiting, n (%) 35 (19.7) 41 (21.1) 76 (20.4) 0.72
Frequency of severe nausea and vomiting AE (Grade ≥ 2) during 1 st cycle of chemotherapy
  Placebo n = 217 Cocculine n = 214 All n = 431 p
Missing data 47 29 76  
Number of patients evaluable, n 170 185 355  
Number of patient with at least 1 severe nausea AE (i.e. Grade ≥2), n (%) 30 (17.6) 29 (15.7) 59 (16.6) 0.62
Missing data 41 22 63  
Number of patients evaluable 176 192 368  
Number of patient with at least 1 severe vomiting AE (i.e. Grade ≥ 2), n (%) 19 (10.8) 23 (12.0) 42 (11.4) 0.72
  1. †Person’s chi-square test.