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Table 1 Study flow-chart (per chemotherapy cycle)

From: Can treatment with Cocculine improve the control of chemotherapy-induced emesis in early breast cancer patients? A randomized, multi-centered, double-blind, placebo-controlled Phase III trial

  Day-1 Day 1 Day 2 Day3 Day4 Day 5 Day 6
Tablets of Cocculine or placebo Evening Morning Noon Evening Morning Noon Evening Morning    
Antiemetic treatment 2 2 2 2 2 2      
Chemotherapy P1 (TAC) S2 + M3   S4 + P1 S4 + P1   S4 + P1 S4 + P1    
Phone call X*   X        X**  
FLIE questionnaire            
Patients diary            X
     X    X X X X  
  1. Po: per os; IV: intraverious; P: Prednisolone; M: Methyprednisolone; S: Ondansetron.
  2. 1: 60 mg po (TAC only); 2: 8 mg IV; 3: 60mg IV; 4: 8 mg po; *: all patients; **: on patients’ request.