Figure 5
From: Up-regulated expression of l-caldesmon associated with malignancy of colorectal cancer
Effect of l -CaD silencing on expression of main cellular signaling proteins. HCT-116 cells was transfeced by CaD siRNA, and whole proteins was extracted at 48 hr after transfection to investigate the expressional change of nine cellular signaling molecules. The expression levels of c-PARP and p21 were increased after l-CaD silencing, but NF-kB and p-mTOR were decreased compared to the non-silencing siRNA transfected cells.