Figure 3
From: Up-regulated expression of l-caldesmon associated with malignancy of colorectal cancer
Expression of l -CaD in rectal cancer patients according to chemoradiation response. (a) Expression pattern of l-CaD (65 kDa) in tissues obtained from rectal cancer patients (RPs), according to Dworak tumor regression grade. Human HCT-116 and SNU-C4 colon cancer cells were used as positive controls for the two caldesmon isoforms. (b) Differential expression of l-CaD (65 kDa) between Dworak tumor regression grade 1 and 4 tumors. The two caldesmon isoforms were detected on Western blots, and their relative expression levels were determined by normalization to actin. Expression of h-CaD (80 kDa) did not differ according to regression grade, whereas expression of l-CaD (65 kDa) was slightly increased in Dworak tumor regression grade 4 tumors but did not reach statistical significance.