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Table 2 Serum testosterone by androgen and estrogen receptor expression in natural postmenopausal women with breast cancer

From: Androgen receptors and serum testosterone levels identify different subsets of postmenopausal breast cancers

 

Testosterone

 

No.

%

Mean ± SD (ng/ml)

P

All natural menopause

    

 AR expression

    

  Absent

59

13.1

0.434 ± 0.198

0.099b 0.002c 0.002d

  Poor

111

24.7

0.385 ± 0.187

  Moderate

120

26.8

0.384 ± 0.166

  High

159

35.4

0.462 ± 0.215

  Totala

449

100.0

0.419 ± 0.196

 

ER-positive

    

 AR expression

    

  Absent

31

8.2

0.451 ± 0.203

0.116b 0.003c 0.022d,f 0.216e,f

  Poor

91

24.1

0.402 ± 0.189

  Moderate

107

28.3

0.385 ± 0.170

  High

149

39.4

0.470 ± 0.217

  Total

378

100.0

0.428 ± 0.200g

 

ER-negative

    

 AR expression

    

  Absent

28

39.4

0.415 ± 0.193

0.510b 0.204c

  Poor

20

28.2

0.310 ± 0.160

  Moderate

13

18.3

0.378 ± 0.124

  High

10

14.1

0.345 ± 0.139

  Total

71

100.0

0.369 ± 0.168g

 
  1. NOTES. Androgen receptor (AR) expression: absent, 0%; poor, ≥1 to 30%; moderate, >30 to 60%; high, >60%. Estrogen receptor (ER)-positive : ER expression ≥10%.
  2. aTwo women had missing information on ER status. bTest for linear trend. cFisher’s test. dLinear contrast comparing AR-high to AR-absent, AR-low and AR-moderate combined. eLinear contrast comparing AR-absent to AR-low and AR-moderate combined. fBonferroni adjusted P value. gFisher’s test P=0.023.
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BMC Cancer

ISSN: 1471-2407

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