SERBP1 is not differentially expressed between normal and malignant human breast tissue in matched pairs. A collection of cryoconserved matched pairs of normal (N; n = 7) and cancerous breast tissues (T; n = 7) was analysed for SERBP1 expression by semiquantitative realtime PCR. SERBP1 RNA was upregulated in three tumour tissues compared to the corresponding normal breast tissues. In four cancerous tissues SERBP1 expression was lower than in the corresponding normal breast tissue. Expression levels between the respective groups were statistically not significant (P = 0.56).