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Table 4 Toxicities according to the National Cancer Institute Common Toxicity Criteria

From: Phase I study of imatinib, cisplatin and 5-fluoruracil or capecitabine in advanced esophageal and gastric adenocarcinoma

Dose level (mg)

1 (300)

2 (400)

3 (500)

4 (600)

5 (700)

Total

 

n

6

3

3

11

2

35

  

Toxicity grade

1/2 3 4

1/2 3 4

1/2 3 4

1/2 3 4

1/2 3 4

1/2 (%)

3 (%)

4 (%)

Hematologic toxicity

Anemia

-

-

-

-

1

-

-

-

-

1

1

-

-

-

-

1 (2,9)

2 (5,7)

-

Neutropenia

-

-

-

1

-

-

1

-

-

1

1

-

-

-

-

3 (8,6)

1(2,9)

-

Thrombocytopenia

-

-

-

-

-

-

2

-

-

1

-

-

-

-

-

3 (8,6)

-

-

Nonhematologic toxicity

Nausea

5

-

-

1

-

-

1

-

-

10

2

-

-

-

-

17 (48,6)

2 (5,7)

-

Vomiting

1

1

-

1

-

-

-

-

-

6

-

-

-

-

-

8 (22,9)

1(2,9)

-

Stomatitis

2

-

-

-

-

-

-

-

-

2

-

-

-

-

-

4 (11,4)

-

-

Diarrhea

3

-

-

-

-

-

-

-

-

14

-

-

-

-

-

17 (48,6)

-

-

Gastrointestinal perforation

-

-

-

-

-

-

-

-

-

-

-

-

-

-

2

-

-

2 (5,7)

Gastrointestinal bleeding

-

-

-

-

-

-

-

-

-

1

1

-

-

-

-

1(2,9)

1(2,9)

-

Constipation

1

1

-

-

-

-

-

-

-

7

-

-

-

-

-

8 (22,9)

1(2,9)

-

Edema / fluid retention

1

-

-

-

-

-

2

1

-

5

-

-

-

-

-

8 (22,9)

1(2,9)

-

Fatigue

-

-

-

1

-

-

-

-

-

10

1

-

-

-

-

11 (31,4)

1(2,9)

-

Fever

-

-

-

1

-

-

-

-

-

1

-

-

-

-

-

2 (5,7)

-

-

Pain

3

-

-

-

-

-

1

-

-

3

2

-

1

-

-

8 (22,9)

2 (5,7)

-

Sensory neuropathy

1

-

-

-

-

-

-

-

-

3

-

-

-

-

-

4 (11,4)

-

-