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Table 4 Toxicities according to the National Cancer Institute Common Toxicity Criteria

From: Phase I study of imatinib, cisplatin and 5-fluoruracil or capecitabine in advanced esophageal and gastric adenocarcinoma

Dose level (mg) 1 (300) 2 (400) 3 (500) 4 (600) 5 (700) Total  
n 6 3 3 11 2 35   
Toxicity grade 1/2 3 4 1/2 3 4 1/2 3 4 1/2 3 4 1/2 3 4 1/2 (%) 3 (%) 4 (%)
Hematologic toxicity
Anemia - - - - 1 - - - - 1 1 - - - - 1 (2,9) 2 (5,7) -
Neutropenia - - - 1 - - 1 - - 1 1 - - - - 3 (8,6) 1(2,9) -
Thrombocytopenia - - - - - - 2 - - 1 - - - - - 3 (8,6) - -
Nonhematologic toxicity
Nausea 5 - - 1 - - 1 - - 10 2 - - - - 17 (48,6) 2 (5,7) -
Vomiting 1 1 - 1 - - - - - 6 - - - - - 8 (22,9) 1(2,9) -
Stomatitis 2 - - - - - - - - 2 - - - - - 4 (11,4) - -
Diarrhea 3 - - - - - - - - 14 - - - - - 17 (48,6) - -
Gastrointestinal perforation - - - - - - - - - - - - - - 2 - - 2 (5,7)
Gastrointestinal bleeding - - - - - - - - - 1 1 - - - - 1(2,9) 1(2,9) -
Constipation 1 1 - - - - - - - 7 - - - - - 8 (22,9) 1(2,9) -
Edema / fluid retention 1 - - - - - 2 1 - 5 - - - - - 8 (22,9) 1(2,9) -
Fatigue - - - 1 - - - - - 10 1 - - - - 11 (31,4) 1(2,9) -
Fever - - - 1 - - - - - 1 - - - - - 2 (5,7) - -
Pain 3 - - - - - 1 - - 3 2 - 1 - - 8 (22,9) 2 (5,7) -
Sensory neuropathy 1 - - - - - - - - 3 - - - - - 4 (11,4) - -