Table 1 Basic characteristics among patients and controls
Cancer patients | Controls | |||||
|---|---|---|---|---|---|---|
Variable | Item | n | % | na | %a | p-value |
total | 21460 | 79331 | ||||
sex | ||||||
male | 12882 | 60.0 | 47621 | 60.0 | ||
female | 8578 | 40.0 | 31710 | 40.0 | ||
age group | ||||||
18-64 years old | 9072 | 42.3 | 33536 | 42.3 | ||
65-100 years old | 12388 | 57.7 | 45795 | 57.7 | ||
income category | ||||||
not working | 6958 | 32.4 | 23361 | 29.4 | <.001 | |
monthly income<= NT$20000 | 11019 | 51.3 | 45805 | 57.7 | ||
monthly income> NT$20000 | 3483 | 16.2 | 10165 | 12.8 | ||
comorbidity in 5 years before index date | ||||||
Myocardial infarction | 486 | 2.3 | 1784 | 2.2 | 0.888 | |
Congestive heart failure | 1864 | 8.7 | 5917 | 7.5 | <.001 | |
Peripheral vascular disease | 609 | 2.8 | 2315 | 2.9 | 0.534 | |
Cerebrovascular disease | 3724 | 17.4 | 13514 | 17.0 | 0.273 | |
Dementia | 655 | 3.1 | 2825 | 3.6 | <.001 | |
Chronic pulmonary disease | 7002 | 32.6 | 25707 | 32.4 | 0.534 | |
Rheumatologic disease | 692 | 3.2 | 2552 | 3.2 | 0.957 | |
Peptic ulcer disease | 7974 | 37.2 | 21875 | 27.6 | <.001 | |
Mild liver disease | 4092 | 19.1 | 12302 | 15.5 | <.001 | |
Diabetes | 4853 | 22.6 | 15049 | 19.0 | <.001 | |
Diabetes with chronic complications | 1462 | 6.8 | 4589 | 5.8 | <.001 | |
Hemiplegia or paraplegia | 416 | 1.9 | 1609 | 2.0 | 0.408 | |
Renal disease | 1833 | 8.5 | 5734 | 7.2 | <.001 | |
Moderate or severe liver disease | 94 | 0.4 | 298 | 0.4 | 0.191 | |
selective COX-2 inhibitors | ||||||
No | 18872 | 87.9 | 69896 | 88.1 | 0.504 | |
Yes | 2588 | 12.1 | 9435 | 11.9 | ||
Average (±sd) DDD | 78.0 (±151.1) | 85.5 (±231.7) | 0.014b | |||
tNSAID | ||||||
No | 2014 | 9.4 | 8517 | 10.7 | <.001 | |
Yes | 19446 | 90.6 | 70814 | 89.3 | ||
Average (±sd) DDD | 87.2 (±145.8) | 94.5 (±170.0) | 0.001b | |||
preferential COX-2 inhibitors | ||||||
No | 15681 | 73.1 | 57451 | 72.4 | 0.058 | |
Yes | 5779 | 26.9 | 21880 | 27.6 | ||
Average (±sd) DDD | 61.6 (±121.9) | 62.2 (144.6) | 0.278b | |||