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Table 2 Associations between LINE-1 methylation in primary CRC and clinicopathological features

From: LINE-1 methylation shows little intra-patient heterogeneity in primary and synchronous metastatic colorectal cancer

   n LINE-1 methylation p-value
Age >70 22 69.5 (62.1 – 70.7) 0.17
  ≤70 21 59.5 (48.4 – 73.4)  
Gender male 25 64.4 (48.9 – 70.4) 0.49
  female 18 68.3 (52.3 – 74.3)  
Site proximal 19 65.3 (53.2 – 69.8) 0.77
  distal 24 69.3 (49.0 – 73.8)  
Histology well 16 68.6 (49.0 – 72.1) 0.98
  moderately 27 65.7 (54.8 – 71.9)  
T factor 1 1 76.3 0.55
  2 7 67.3 (49.3 – 70.7)  
  3 26 67.3 (49.3 – 70.7)  
  4 9 58.2 (48.2 – 69.3)  
N factor 0 20 69.5 (49.7 – 75.0) 0.67
  1 16 59.4 (48.9 – 74.1)  
  2 7 65.7 (62.9 – 68.0)  
M factor 0 34 67.3 (50.3 – 73.8) 0.49
  1 9 60.7 (48.2 – 70.0)  
Stage I 4 72.3 (69.5 – 75.0) 0.47
  II 15 69.3 (49.4 – 73.8)  
  III 15 64.4 (50.5 – 68.1)  
  IV 9 60.7 (48.2 – 70.0)  
  1. n, number of patients.
  2. LINE-1 methylation levels are shown as the median (25th percentile – 75th percentile).
  3. Histology of adenocarcinoma was sub-classified into well- and moderately-differentiated adenocarcinoma according to their grading.
  4. TNM factors and stage were defined according to the International Union Against Cancer (UICC) TNM system.