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Table 2 Associations between LINE-1 methylation in primary CRC and clinicopathological features

From: LINE-1 methylation shows little intra-patient heterogeneity in primary and synchronous metastatic colorectal cancer

  

n

LINE-1 methylation

p-value

Age

>70

22

69.5 (62.1 – 70.7)

0.17

 

≤70

21

59.5 (48.4 – 73.4)

 

Gender

male

25

64.4 (48.9 – 70.4)

0.49

 

female

18

68.3 (52.3 – 74.3)

 

Site

proximal

19

65.3 (53.2 – 69.8)

0.77

 

distal

24

69.3 (49.0 – 73.8)

 

Histology

well

16

68.6 (49.0 – 72.1)

0.98

 

moderately

27

65.7 (54.8 – 71.9)

 

T factor

1

1

76.3

0.55

 

2

7

67.3 (49.3 – 70.7)

 
 

3

26

67.3 (49.3 – 70.7)

 
 

4

9

58.2 (48.2 – 69.3)

 

N factor

0

20

69.5 (49.7 – 75.0)

0.67

 

1

16

59.4 (48.9 – 74.1)

 
 

2

7

65.7 (62.9 – 68.0)

 

M factor

0

34

67.3 (50.3 – 73.8)

0.49

 

1

9

60.7 (48.2 – 70.0)

 

Stage

I

4

72.3 (69.5 – 75.0)

0.47

 

II

15

69.3 (49.4 – 73.8)

 
 

III

15

64.4 (50.5 – 68.1)

 
 

IV

9

60.7 (48.2 – 70.0)

 
  1. n, number of patients.
  2. LINE-1 methylation levels are shown as the median (25th percentile – 75th percentile).
  3. Histology of adenocarcinoma was sub-classified into well- and moderately-differentiated adenocarcinoma according to their grading.
  4. TNM factors and stage were defined according to the International Union Against Cancer (UICC) TNM system.
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BMC Cancer

ISSN: 1471-2407

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