Figure 4
From: Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin
Starvation sensitizes human lung carcinoma A549 xenografts to CDDP in vivo. A, Western blot results with antibodies against phospho Chk2-T68, Chk2, γ-H2AX and p53 for protein extracts from untreated control A549 cells and those treated with CDDP alone, serum starvation alone, or both together are shown. β-Actin was used as loading control. B, growth curves of A549 tumors in the untreated control animal group and those treated with CDDP, STS, or both together (n=6/group) (** P<0.011). C, complete tumor remission is observed only with the CDDP treatment combined with STS. The arrows in (B) indicate the time points of individual treatments.