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Table 4 Effect of TLR2 and TLR9 SNPs for α-FP level and UICC pathologic stage in patients with hepatocellular carcinoma

From: The association between Toll-like receptor 2 single-nucleotide polymorphisms and hepatocellular carcinoma susceptibility

Gene SNP Genotype Odds Ratio (95% CI) † P Value Odds Ratio (95% CI) ‡ P Value
TLR2 rs7696323 C/C 1   1  
   C/T 0.623 (0.339 - 1.142) 0.126 0.703 (0.393 - 1.257) 0.235
   T/T 0.639 (0.241 - 1.693) 0.368 0.402 (0.156 - 1.038) 0.060
  rs1898830 A/A 1   1  
   A/G 0.491 (0.771 - 2.885) 0.235 1.434 (0.740 - 2.635) 0.237
   G/G 2.137 (0.994 - 4.597) 0.052 1.304 (0.624 - 2.726) 0.480
  rs11938228 C/C 1   1  
   A/C 1.702 (0.894 - 3.239) 0.106 1.421 (0.771 - 2.616) 0.260
   A/A 1.656 (0.764 - 3.587) 0.201 1.458 (0.693 - 3.479) 0.590
  rs3804099 T/T 1   1  
   C/T 1.140 (0.623 - 2.083) 0.671 1.160 (0.644 - 2.088) 0.621
   C/C 0.808 (0.287 - 2.276) 0.686 1.308 (0.492 - 3.479) 0.590
  rs3804100 T/T 1   1  
   C/T 1.192 (0.651 - 2.183) 0.569 1.232 (0.681 - 2.230) 0.490
   C/C 0.706 (0.210 - 2.377) 0.575 0.940 (0.312 - 2.832) 0.913
TLR9 rs352140 C/C 1   1  
   C/T 0.928 (0.511 - 1.685) 0.805 0.875 (0.487 - 1.573) 0.655
   T/T 0.465 (0.137 - 1.076) 0.054 0.595 (0.260 - 1.360) 0.218
  rs352139 G/G 1   1  
   G/A 1.106 (0.609 - 2.008) 0.741 1.051 (0.587 - 1.884) 0.866
   A/A 0.470 (0.171 - 1.292) 0.143 0.691 (0.288 - 1.656) 0.407
  1. † α-FP level: > 400 ng/ml or < = 400 ng/ml
  2. ‡ UICC classification: stage I, II or stage III, IV