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Table 2 Distribution of CYP2D6 alleles and genotypes

From: Reduced CYP2D6 function is associated with gefitinib-induced rash in patients with non-small cell lung cancer

Alleles

Number

CYP2D6*1

236 (40.8%)

CYP2D6*2

63 (10.9%)

CYP2D6*10

211 (36.5%)

CYP2D6*14A

1 (0.2%)

Genotype

Number

Functional

 

CYP2D6*1/*1

67 (23.2%)

CYP2D6*1/*2

22 (7.6%)

CYP2D6*1/*10

72 (24.9%)

CYP2D6*1/*14A

1 (0.4%)

CYP2D6*1/undetermined

7 (2.4%)

CYP2D6*2/*2

9 (3.1%)

CYP2D6*2/*10

20 (6.9%)

CYP2D6*2/undetermined

3 (1.0%)

Total

201 (69.6%)

Reduced

 

CYP2D6*10/*10

58 (20.1%)

Unknown

 

CYP2D6*10/ undetermined

3 (1.0%)

undetermined/ undetermined

27 (9.3%)

Total

30 (10.3%)

  1. CYP2D6, cytochrome P450 2D6.