From: Expression profile and prognostic role of sex hormone receptors in gastric cancer
Variable | Total patients (n = 866) | Evaluable patients† | |||||||
---|---|---|---|---|---|---|---|---|---|
ERα (n = 848) | ERβ (n = 823) | PR (n = 851) | AR (n = 843) | ||||||
Positive No. (%) | P‡ | Positive No. (%) | P‡ | Positive No. (%) | P‡ | Positive No. (%) | P‡ | ||
Sex | 0.496 | 0.166 | 0.522 | 0.313 | |||||
Female | 261 | 29 (10.9) | 221 (89.8) | 58 (21.9) | 81 (30.6) | ||||
Male | 605 | 73 (12.5) | 535 (92.7) | 140 (23.9) | 197 (34.1) | ||||
Age, years | 0.837 | 0.187 | 0.523 | 0.254 | |||||
≤40 | 70 | 6 (8.8) | 57 (87.7) | 12 (17.6) | 16 (24.2) | ||||
≤50 | 148 | 19 (13.2) | 126 (93.3) | 30 (20.7) | 46 (32.2) | ||||
≤65 | 328 | 39 (12.0) | 283 (90.1) | 79 (24.5) | 102 (31.9) | ||||
>65 | 320 | 38 (12.2) | 290 (93.9) | 77 (24.4) | 114 (36.3) | ||||
Tumor site§ | 0.839 | 0.700 | 0.433 | 0.605 | |||||
Upper | 138 | 19 (13.8) | 123 (91.8) | 25 (18.2) | 52 (38.0) | ||||
Middle | 263 | 30 (11.8) | 224 (90.3) | 63 (24.3) | 81 (31.9) | ||||
Lower | 416 | 46 (11.3) | 368 (92.9) | 100 (24.6) | 129 (32.0) | ||||
Diffuse | 49 | 7 (14.3) | 41 (91.1) | 10 (20.4) | 16 (32.7) | ||||
Tumor size, cm | 0.166 | 0.316 | 0.425 | 0.127 | |||||
≤2 | 133 | 22 (17.1) | 117 (95.9) | 28 (22.0) | 52 (42.3) | ||||
≤3 | 160 | 21 (13.7) | 134 (89.9) | 29 (18.6) | 50 (32.3) | ||||
≤5 | 273 | 30 (11.1) | 243 (91.7) | 67 (24.7) | 84 (31.3) | ||||
>5 | 300 | 29 (9.8) | 262 (91.3) | 74 (24.9) | 92 (31.0) | ||||
Tumor grade | <0.001 | 0.030 | 0.001 | <0.001 | |||||
Well | 48 | 15 (31.9) | 53 (96.4) | 19 (40.4) | 22 (48.9) | ||||
Moderate | 286 | 47 (16.5) | 274 (94.5) | 77 (27.1) | 127 (44.9) | ||||
Poor | 532 | 40 (7.8) | 429 (89.7) | 102 (19.6) | 129 (25.0) | ||||
Lauren type | 0.012 | 0.010 | 0.017 | <0.001 | |||||
Intestinal | 535 | 76 (14.4) | 481 (93.0) | 139 (26.3) | 197 (37.6) | ||||
Diffuse | 297 | 21 (7.4) | 250 (91.2) | 55 (19.0) | 68 (23.9) | ||||
Mixed | 34 | 5 (14.7) | 25 (78.1) | 4 (11.8) | 13 (38.2) | ||||
T classification¶ | <0.001 | 0.195 | 0.818 | <0.001 | |||||
pT1 | 132 | 33 (26.0) | 114 (95.0) | 28 (21.7) | 61 (48.8) | ||||
pT2 | 142 | 19 (13.9) | 125 (94.7) | 36 (26.3) | 49 (36.6) | ||||
pT3 | 528 | 44 (8.4) | 463 (90.8) | 120 (23.0) | 147 (28.2) | ||||
pT4 | 64 | 6 (9.7) | 54 (88.5) | 14 (22.2) | 21 (33.9) | ||||
N classification¶ | <0.001 | 0.574 | 0.340 | 0.001 | |||||
pN0 | 309 | 67 (22.3) | 272 (93.2) | 76 (25.0) | 125 (41.9) | ||||
pN1 | 314 | 20 (6.5) | 275 (90.2) | 63 (20.7) | 85 (28.0) | ||||
pN2 | 191 | 13 (6.9) | 165 (92.7) | 43 (22.6) | 52 (27.4) | ||||
pN3 | 52 | 2 (3.9) | 44 (91.7) | 16 (30.8) | 16 (31.4) | ||||
TNM stage¶ | <0.001 | 0.173 | 0.535 | <0.001 | |||||
I | 187 | 44 (24.4) | 165 (95.4) | 48 (26.2) | 85 (47.8) | ||||
II | 158 | 21 (13.5) | 138 (90.8) | 39 (25.3) | 53 (35.1) | ||||
III | 294 | 23 (8.0) | 253 (89.7) | 61 (21.0) | 74 (25.3) | ||||
IV | 227 | 14 (6.3) | 200 (92.6) | 50 (22.3) | 66 (29.7) |