|
AURKA
|
P-value
|
<0.001
|
<0.001
|
0.005
|
<0.001
|
|
HR
|
1.927
|
1.952
|
1.520
|
1.669
|
|
95%-CI
|
1.335-2.782
|
1.448-2.632
|
1.135-2.036
|
1.402-1.986
|
|
B. Multivariate Cox analysis of MFS adjusted to established clinical factors (combined Mainz and Transbig cohorts, n=465)
|
| |
p
|
HR
|
95
%
CI
|
|
Age (<50 vs. ≥50 years)
|
0.392
|
1.180
|
0.808-1.726
|
|
pT stage (≤2cm vs. >2cm)
|
0.005
|
1.812
|
1.192-2.754
|
|
Histological grade (Grade 1 and 2 vs. grade 3)
|
0.087
|
1.529
|
0.940-2.487
|
|
ER status (negative vs. positive)
|
0.413
|
1.214
|
0.763-1.931
|
|
HER2 status (negative vs. positive)
|
0.415
|
1.248
|
0.732-2.128
|
|
AURKA (continuous variable)
|
0.046
|
1.350
|
1.005-1.812
|
