Figure 5

Metastasis free survival likeliehood statistics as described by Prat et al., [[32]]. To compare the amount of independent prognostic information provided by grading (A) and AURKA (B) we estimated the likelihood ratio statistic in a model that already included AURKA (A) or grading (B). The model shows that AURKA provides significant additional information over grading in the cohort of all patients, as well as in the ER+/HER2- and in the HER2+ subgroups (B). Vice versa, grading provides additional information over AURKA only in the subcohort ofHER2+ patients (A).