|
Outcome
|
# studies
|
Pooled effect
| | | |
Test of heterogeneity
| | |
|---|
|
Physical outcomes
| |
d
|
95% CI
|
Z
|
P
|
I2
|
Q
|
P
|
|---|
|
Physical function
|
6
|
0.60
|
−0.05 to 1.25
|
1.81
|
0.07
|
87.51
|
40.03
|
<0.0001
|
| |
5a
|
0.17
|
−0.06 to 0.40
|
1.48
|
0.14
|
0.00
|
1.20
|
0.88
|
|
Functional well-being
|
4
|
0.31
|
0.04 to 0.58
|
2.24
|
0.03
|
0.00
|
1.25
|
0.74
|
|
Psychosocial outcomes
| |
d
|
95% CI
|
Z
|
P
|
I
2
|
Q
|
P
|
|
Distress
|
7
|
−0.95
|
−1.49 to −0.49
|
−4.04
|
<0.001
|
80.79
|
31.24
|
<0.001
|
| |
6b
|
−0.75
|
−1.09 to −0.42
|
−4.39
|
<0.001
|
59.59
|
12.37
|
0.03
|
|
Anxiety
|
7
|
−1.25
|
−1.93 to −0.56
|
−3.64
|
<0.001
|
91.45
|
70.20
|
<0.001
|
| |
6b
|
−0.77
|
−1.08 to −0.46
|
−4.86
|
<0.001
|
58.42
|
12.03
|
0.03
|
|
Depression
|
7
|
−1.47
|
−2.42 to −0.53
|
−3.05
|
0.002
|
93.29
|
89.46
|
<0.001
|
| |
6b
|
−0.69
|
−1.02 to −0.37
|
−4.21
|
<0.001
|
42.15
|
8.64
|
0.12
|
|
Fatigue
|
7
|
−0.51
|
−0.79 to −0.22
|
−3.46
|
0.001
|
43.52
|
10.62
|
0.10
|
|
Sleep disturbance
|
4
|
−0.26
|
−0.53 to 0.02
|
−1.82
|
0.07
|
0.00
|
1.25
|
0.74
|
|
General HRQoL
|
7
|
0.88
|
0.25 to 1.50
|
2.75
|
0.006
|
86.49
|
44.41
|
<0.001
|
| |
6a
|
0.61
|
0.16 to 1.06
|
2.50
|
0.008
|
69.79
|
16.55
|
0.005
|
| |
5a,c
|
0.37
|
0.11 to 0.62
|
2.85
|
0.004
|
0.00
|
3.40
|
0.49
|
|
Emotional function
|
5
|
0.49
|
0.16 to 0.81
|
2.93
|
0.003
|
26.58
|
5.45
|
0.24
|
|
Social function
|
6
|
0.33
|
0.12 to 0.54
|
3.12
|
0.002
|
0.00
|
1.94
|
0.86
|
-
a Excluding outlier Chandwani et al. 2010 [55]; b Excluding outlier Banerjee et al. [51]. c Excluding outlier Raghavendra et al. 2007 [49].
