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Figure 2 | BMC Cancer

Figure 2

From: Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt

Figure 2

Salinomycin causes a decrease in cell viability and induces apoptosis. (A) MTS assay shows salinomycin causes a selective decrease in cell proliferation of JLO-1 compared to UMSCC-10B. The absorbance values (Y-axis) were normalized by dividing over the absorbance of each control. Error bars represent standard deviation. (B) TUNEL assay shows an increase in apoptosis with a 2 μM salinomycin treatment indicated by the percent increase in DNA strand breaks. (C) Western blot demonstrates a dose dependent increase in apoptosis as seen by the induction in Bax/Bcl-2 ratio.

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BMC Cancer

ISSN: 1471-2407

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