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Table 5 Summary of studies reporting HER2 status in primary breast cancer and metastases

From: A retrospective study investigating the rate of HER2 discordance between primary breast carcinoma and locoregional or metastatic disease

Author

Patient numbers

“Gain” in HER2

“Loss” of HER2

Giotta [8]

20

5%

5%

Gancberg [9]:

   

Immunohistochemistry

100

6%

-

In situ hybridisation

68

4%

3%

Nikura [10]

182

-

24%

Amir [11]

83

8% (6/73)

20% (2/10)

Gong [12]

60

1.6%

1.6%

Tapia [13]

105

1.9%

0.9%

Fabi [14]

137

8.7%

1.5%

Simon [15]

122

2.2%

6.5%

Lindstrom [16]

76

6.5%

10.5%