Figure 7

PTEN status is associated with AR signalling. GSEA was performed with previously published gene expression data of 64 prostate tumors (Lapointe et al.) stratified by their PTEN genomic status. Two androgen responsive gene sets were tested: A) a curated set of 71 genes (NELSON_RESPONSE_TO_ANDROGEN_UP, Nelson et al.) from the Molecular Signatures database (MSigDB, C2) and B) a set of 204 genes reported by DePrimo et al. GSEA identified enrichment of androgen responsive genes in PTEN positive samples. The enrichment score (ES, y-axis) reflects the degree to which an androgen responsive gene set is overrepresented at the top ranked list of genes according to the PTEN status (ranked in descending order from left to right, x-axis). Enrichment is evidenced by the early positive deflection of the running sum curve (blue line). A thousand permutations were done and the false discovery rate estimated (FDR). C) Genes from Nelson et al. that contribute to the enrichment core.