Figure 5

PTEN deletion predicts disease recurrence in an independent PCa cohort. A) In the dataset of Lapointe et al., PTEN deletion status of 64 PCa as determined by array CGH was associated with low PTEN mRNA levels measured by gene expression profiling. The box-plot shows the mean (+ sign), the 25th, 50th (median), 75th percentiles of PTEN expression including the minimum and maximum (unequal variance t-test, P-Value indicated). Values are reported as log2 ratios, normalized to the sample-set mean. B) Kaplan-Meier analysis of recurrence-free survival based on PTEN deletion status of a subset of the PCa cohort for which the clinical follow-up was available (n=29). P-value (log-rank test) indicated.