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Figure 5 | BMC Cancer

Figure 5

From: Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses

Figure 5

The boxplot of AUC by genotype; AOX1(c3404 A>G), UGT1A1*28 or CYP2D6. A:The boxplot of TP3076 AUC by AOX1(c3404 A>G). B:The boxplot of TP3011 AUC by AOX1(c3404 A>G). C:The boxplot of TP3076 AUC by UGT1A1 *28. D:The boxplot of TP3011 AUC by UGT1A1 *28. E:The boxplot of TP3076 AUC by CYP genotype. F:The boxplot of TP3011 AUC by CYP genotype. E: Extensive metabolizer. I:Intermediate metabolizer. P:Poor metabolizer.

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