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Table 1 Statistics for counts of non-silent mtDNA variants organized by electron transfer chain complex.

From: Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors

  Oncocytic vs Non-oncocytic Oncocytic vs General Cancer Non-oncocytic vs General Cancer
Complex I,
p-value
0.003 0.00002 0.77
Complex I,
OR [CI]
7.4 [2 - 27] 5.6 [2.4 - 13] NS
Complex III,
p-value
0.58 0.44 0.23
Complex III, OR [CI] NS NS NS
Complex IV,
p-value
0.034 0.0004 1
Complex IV, OR [CI] 0.11 [0.02 - 0.75] 0.1 [0.02 - 0.4] NS
Complex V,
p-value
0.003 0.16 0.03
Complex V,
OR [CI]
0.04 [0.004 - 0.37] NS 5 [1.3 - 19]
  1. NS = not significant