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Table 1 Statistics for counts of non-silent mtDNA variants organized by electron transfer chain complex.

From: Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors

 

Oncocytic vs Non-oncocytic

Oncocytic vs General Cancer

Non-oncocytic vs General Cancer

Complex I,

p-value

0.003

0.00002

0.77

Complex I,

OR [CI]

7.4 [2 - 27]

5.6 [2.4 - 13]

NS

Complex III,

p-value

0.58

0.44

0.23

Complex III, OR [CI]

NS

NS

NS

Complex IV,

p-value

0.034

0.0004

1

Complex IV, OR [CI]

0.11 [0.02 - 0.75]

0.1 [0.02 - 0.4]

NS

Complex V,

p-value

0.003

0.16

0.03

Complex V,

OR [CI]

0.04 [0.004 - 0.37]

NS

5 [1.3 - 19]

  1. NS = not significant