Table 2 CYP1A2 rs762551 polymorphism and cancer risk stratified by characteristics of studies
Variables | Genotype of rs762551 (Cases/Controls) | CC vs AA | Dominant model (CC+CA vs AA) | Recessive model (CC vs CA+AA) | |||
|---|---|---|---|---|---|---|---|
| Â | Total | AA | AC | CC | OR (95% CI) | OR (95% CI) | OR (95% CI) |
All | 8218/11165 | 3750/5374 | 3567/4720 | 901/1071 | 1.30(1.02-1.64)* | 1.19(1.04-1.36)* | 1.19(0.99-1.44) |
Cancer site | Â | Â | Â | Â | Â | Â | Â |
 Lung | 814/1018 | 277/426 | 380/443 | 157/149 | 1.27(0.63-2.61) | 1.09(0.63-1.89) | 1.27(0.82-1.95) |
 Colorectal | 734/747 | 288/366 | 362/310 | 84/71 | 1.50(0.96-2.33) | 1.52(0.95-2.42) | 1.15(0.73-1.81) |
 Breast | 5274/7874 | 2544/3848 | 2204/3331 | 526/695 | 1.44(0.82-2.55) | 1.07(0.93-1.24) | 1.15(0.73-1.81) |
 Other | 1396/1526 | 641/734 | 621/636 | 134/156 | 1.04(0.79-1328) | 1.12(0.96-1.31) | 0.97(0.73-1.30) |
Ethnicity | Â | Â | Â | Â | Â | Â | Â |
 Caucasian | 5751/8345 | 2804/4199 | 2417/3463 | 530/683 | 1.29(1.27-1.63)* | 1.17(1.02-1.34)* | 1.19(0.98-1.45) |
 Asian | 2253/2423 | 867/989 | 1055/1086 | 331/348 | 1.27(0.83-1.93) | 1.24(0.93-1.66) | 1.10(0.76-1.59) |
 Mixed | 214/397 | 79/186 | 95/171 | 40/40 | 1.34(0.14-12.95) | 0.87(0.17-4.40) | 1.68(0.44-6.35) |
Source of Controls | Â | Â | Â | Â | Â | Â | Â |
 Population | 5549/7936 | 2590/3777 | 2388/3387 | 571/772 | 1.01(0.89-1.14) | 1.02(0.92-1.14) | 1.00(0.89-1.13) |
 Hospital | 2556/2930 | 1114/1426 | 1128/1219 | 314/285 | 1.35(0.97-1.88) | 1.21(0.98-1.50) | 1.26(0.96-1.65) |
 Other | 113/299 | 46/171 | 51/114 | 16/14 | 4.25(1.93-9.34)* | 1.95(1.25-3.02)* | 3.36(1.58-7.13)* |