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Table 3 Subcellular localization of Ep-ICD and EpEx in metastatic and non-metastatic PTMC

From: Immunohistochemical analysis based Ep-ICD subcellular localization index (ESLI) is a novel marker for metastatic papillary thyroid microcarcinoma

Protein localization

Metastatic (mean ± SD)

Non-metastatic (mean ± SD)

P-value

AUC

A.sig

EpEx cytoplasm

3.00 ± 1.67

1.91 ± 1.16

0.095

0.694

0.098

EpEx membrane

4.64 ± 1.08

5.64 ± 1.51

0.026

0.243

0.029

Loss of membranous EpEx

2.36 ± 1.08

1.36 ± 1.51

0.026

0.757

0.029

Ep-ICD nucleus

1.96 ± 0.86

1.22 ± 0.45

0.007

0.783

0.016

Ep-ICD cytoplasm

5.37 ± 0.33

4.72 ± 1.07

0.016

0.766

0.024

Ep-ICD membrane

1.30 ± 1.07

1.93 ± 1.61

0.348

0.391

0.351

ESLI (loss of membranous EpEx + Ep-ICDnuc + Ep-ICD cyto)

9.69 ± 2.01

7.30 ± 2.39

0.008

0.808

0.009