Figure 3

Dot plot analysis of Ep-ICD and membranous EpEx expression in papillary thyroid microcarcinoma patients. Dot plot shows the distribution of total IHC scores for Ep-ICD (A); EpEx and ESLI (B). The vertical axis gives the IHC score as described in the Methods section. Increased nuclear expression of Ep-ICD was more frequently observed in the metastatic PTMC group as compared to the non-metastatic PTMCs (A). High membrane EpEx expression was observed in non-metastatic PTMCs, whereas decreased membranous expression of EpEx was observed in most of the aggressive PTMC cases analyzed (B). An increase in ESLI was observed in the metastatic PTMC group as compared to the non-metastatic PTMCs (B). Abbreviations: NM, non-metastatic; M, metastatic.