Figure 2From: Spatial morphological and molecular differences within solid tumors may contribute to the failure of vascular disruptive agent treatments Preferential accumulation of immune cells in the tumor periphery. Formalin fixed liver sections with CRC liver metastases were stained with anti-CD3, anti-FOXP3 and F4/80 monoclonal antibodies to detect the presence of T cells, regulatory T cells and macrophages respectively. Low magnification scale bar=250μm, high magnification scale bar=50μm. Quantification of each cell type revealed significant differences between the tumor center and the periphery. Data is expressed as mean value of positive cells/ mm2±SEM with n≥5 for each group. (*P=0.0001 for T cells and regulatory T cells and #P=0.021 for macrophages).Back to article page