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Table 2 AUC values for disease prediction considering uPA, PAI-1, TF and age1

From: Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy

Biomarker

Group

N 1

AUC

   

CA/no CA 2

CA/benign 2

Abnormal/benign 2

uPA+PAI-1

All

79

.72

.75

.74

uPA3

Pre

38

.87

.83

.86

TF4

Post

72

.81

.83

.83

TF+uPA

All

35

.84

.92

.91

TF+uPA+PAI-1

All

24

1.0

1.0

.97

  1. 1AUC: area under the receiver operating curve; uPA: urinary plasminogen activator; PAI (uPA inhibitor)-1, TF: Thomsen-Friedenreich antigen; N = number or sample size. The equivalent values as percent should be multiplied by 100 (i.e., .97 = 97%, and so forth)
  2. 2Cancer = ductal carcinoma in situ (DCIS), and invasive cancer; Benign = normal and hyperplasia; Abnormal = atypical hyperplasia, DCIS, and invasive cancer. Age is in all three models
  3. 3AUC values for postmenopausal women were lower
  4. 4previously published data [9]
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BMC Cancer

ISSN: 1471-2407

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