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Table 2 AUC values for disease prediction considering uPA, PAI-1, TF and age1

From: Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy

Biomarker Group N 1 AUC
    CA/no CA 2 CA/benign 2 Abnormal/benign 2
uPA+PAI-1 All 79 .72 .75 .74
uPA3 Pre 38 .87 .83 .86
TF4 Post 72 .81 .83 .83
TF+uPA All 35 .84 .92 .91
TF+uPA+PAI-1 All 24 1.0 1.0 .97
  1. 1AUC: area under the receiver operating curve; uPA: urinary plasminogen activator; PAI (uPA inhibitor)-1, TF: Thomsen-Friedenreich antigen; N = number or sample size. The equivalent values as percent should be multiplied by 100 (i.e., .97 = 97%, and so forth)
  2. 2Cancer = ductal carcinoma in situ (DCIS), and invasive cancer; Benign = normal and hyperplasia; Abnormal = atypical hyperplasia, DCIS, and invasive cancer. Age is in all three models
  3. 3AUC values for postmenopausal women were lower
  4. 4previously published data [9]
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BMC Cancer

ISSN: 1471-2407

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