Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy

Table 1 Univariate analyses of uPA and PAI-1 expression (ng/mL) in women requiring breast surgery

A. Cancer/no cancer		Overall	No cancer¹	Cancer¹	P value
*All Subjects (N)*		79	46	33
uPA	Mean (SD)	2.4 (.90)	2.2 (.84)	2.7 (.92)	.023
	Median	2.4	2.2	2.6
PAI-1	Mean (SD)	3.7 (1.5)	3.4 (1.4)	4.2 (1.6)	.064
	Median	3.5	3.3	4.1
*Premenopausal (N)*		38	23	15
uPA	Mean (SD)	2.5 (.93)	2.2 (.82)	2.9 (.93)	.018
	Median	2.5	2.3	2.7
*Postmenopausal (N)*		41	23	18
PAI-1	Mean (SD)	4.0 (1.6)	3.5 (1.6)	4.6 (1.4)	.025
	Median	3.8	3.3	4.3
B. Cancer/benign		Overall	Benign ¹	Cancer ¹	P value
*All Subjects (N)*		72	39	33
uPA	Mean (SD)	2.4 (.93)	2.2 (.89)	2.7 (.92)	.025
	Median	2.4	2.2	2.6
PAI-1	Mean (SD)	3.7 (1.5)	3.4 (1.4)	4.2 (1.6)	.037
	Median	3.4	3.1	4.1
*Premenopausal (N)*		37	22	15
uPA	Mean (SD)	2.4 (.95)	2.2 (.84)	2.9 (.93)	.017
	Median	2.5	2.2	2.7
*Postmenopausal (N)*		35	17	18
PAI-1	Mean (SD)	4.0 (1.7)	3.4 (1.7)	4.6 (1.4)	.033
	Median	3.8	2.8	4.3
C. Abnormal/benign		Overall	Benign ¹	Abnormal ¹	P value
*All Subjects (N)*		79	39	40
uPA	Mean (SD)	2.4 (.90)	2.2 (.89)	2.6 (.88)	.050
	Median	2.4	2.2	2.5
PAI-1	Mean (SD)	3.7 (1.5)	3.4 (1.4)	4.0 (1.6)	.060
	Median	3.5	3.1	3.9
*Premenopausal (N)*		38	22	16
uPA	Mean (SD)	2.5 (.93)	2.2 (.84)	2.9 (.91)	.018
	Median	2.5	2.2	2.7
*Postmenopausal (N)*		41	17	24
PAI-1	Mean (SD)	4.0 (1.6)	3.4 (1.7)	4.4 (1.3)	.052
	Median	3.8	2.8	4.1

¹No cancer = normal, hyperplasia, and atypical hyperplasia; Cancer = ductal carcinoma in situ and invasive cancer; Benign = normal and hyperplasia; Abnormal = atypical hyperplasia, ductal carcinoma in situ and invasive cancer. Means and medians reflect log10 values for each marker. For all subjects, all p values are provided regardless of the result. For pre- and postmenopausal groupings, only results which were significant or approached significance (p < .065) were included

ISSN: 1471-2407