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Table 1 Univariate analyses of uPA and PAI-1 expression (ng/mL) in women requiring breast surgery

From: Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy

A. Cancer/no cancer Overall No cancer1 Cancer1 P value
All Subjects (N) 79 46 33  
uPA Mean (SD) 2.4 (.90) 2.2 (.84) 2.7 (.92) .023
  Median 2.4 2.2 2.6  
PAI-1 Mean (SD) 3.7 (1.5) 3.4 (1.4) 4.2 (1.6) .064
  Median 3.5 3.3 4.1  
Premenopausal (N) 38 23 15  
uPA Mean (SD) 2.5 (.93) 2.2 (.82) 2.9 (.93) .018
  Median 2.5 2.3 2.7  
Postmenopausal (N) 41 23 18  
PAI-1 Mean (SD) 4.0 (1.6) 3.5 (1.6) 4.6 (1.4) .025
  Median 3.8 3.3 4.3  
B. Cancer/benign Overall Benign 1 Cancer 1 P value
All Subjects (N) 72 39 33  
uPA Mean (SD) 2.4 (.93) 2.2 (.89) 2.7 (.92) .025
  Median 2.4 2.2 2.6  
PAI-1 Mean (SD) 3.7 (1.5) 3.4 (1.4) 4.2 (1.6) .037
  Median 3.4 3.1 4.1  
Premenopausal (N) 37 22 15  
uPA Mean (SD) 2.4 (.95) 2.2 (.84) 2.9 (.93) .017
  Median 2.5 2.2 2.7  
Postmenopausal (N) 35 17 18  
PAI-1 Mean (SD) 4.0 (1.7) 3.4 (1.7) 4.6 (1.4) .033
  Median 3.8 2.8 4.3  
C. Abnormal/benign Overall Benign 1 Abnormal 1 P value
All Subjects (N) 79 39 40  
uPA Mean (SD) 2.4 (.90) 2.2 (.89) 2.6 (.88) .050
  Median 2.4 2.2 2.5  
PAI-1 Mean (SD) 3.7 (1.5) 3.4 (1.4) 4.0 (1.6) .060
  Median 3.5 3.1 3.9  
Premenopausal (N) 38 22 16  
uPA Mean (SD) 2.5 (.93) 2.2 (.84) 2.9 (.91) .018
  Median 2.5 2.2 2.7  
Postmenopausal (N) 41 17 24  
PAI-1 Mean (SD) 4.0 (1.6) 3.4 (1.7) 4.4 (1.3) .052
  Median 3.8 2.8 4.1  
  1. 1No cancer = normal, hyperplasia, and atypical hyperplasia; Cancer = ductal carcinoma in situ and invasive cancer; Benign = normal and hyperplasia; Abnormal = atypical hyperplasia, ductal carcinoma in situ and invasive cancer. Means and medians reflect log10 values for each marker. For all subjects, all p values are provided regardless of the result. For pre- and postmenopausal groupings, only results which were significant or approached significance (p < .065) were included