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Table 2 Associations between calpastatin, calpain-1 and calpain-2 protein expression and various clinicopathological variables in the bile duct and ampullary cancer cohort

From: Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla

Variable

Calpain-1

Calpain-2

Calpastatin (cytoplasmic)

Calpastatin (nuclear)

 

Low

High

p value

Low

High

p value

Low

High

p value

Low

High

p value

Age

            

 ≤ 60 years (n=40)

12 (30.0)

27 (38.6)

0.366

14 (36.8)

22 (34.9)

0.845

16 (50.0)

22 (28.9)

0.036

25 (35.7)

12 (32.4)

0.734

 > 60 years (n=78)

28 (70.0)

43 (61.4)

24 (63.2)

41 (65.1)

16 (50.0)

54 (71.1)

45 (64.3)

25 (67.6)

Tumour size

            

 ≤ 2cm (n=48)

15 (37.5)

29 (40.8)

0.729

18 (46.2)

21 (33.3)

0.195

17 (51.5)

27 (35.5)

0.118

30 (42.3)

13 (35.1)

0.473

 > 2cm (n=70)

25 (62.5)

42 (59.2)

21 (53.8)

42 (66.7)

16 (48.5)

49 (64.5)

41 (57.7)

24 (64.9)

T stage

            

 1 (n=3)

0 (0.0)

3 (4.2)

0.262

0 (0.0)

3 (4.7)

0.137

1 (3.0)

2 (2.6)

0.918

0 (0.0)

3 (8.1)

0.026

 2 (n=27)

11 (26.8)

13 (18.3)

7 (17.9)

15 (23.4)

8 (24.2)

17 (22.1)

20 (27.8)

5 (22.9)

 3 (n=86)

28 (68.3)

54 (76.1)

30 (76.9)

46 (71.9)

23 (69.7)

57 (74.0)

50 (69.4)

29 (78.4)

 4 (n=3)

2 (4.9)

1 (1.4)

2 (5.1)

0 (0.0)

1 (3.0)

1 (1.8)

2 (2.8)

0 (0.0)

N stage

            

 Negative (n=44)

14 (35.9)

28 (41.2)

0.590

14 (37.8)

24 (39.3)

0.882

11 (35.5)

30 (40.5)

0.628

26 (38.2)

15 (41.7)

0.733

 Positive (n=69)

25 (64.1)

40 (58.8)

23 (62.2)

37 (60.7)

20 (64.5)

44 (59.5)

42 (61.8)

21 (58.3)

Vascular invasion

            

 absent (n=52)

18 (43.9)

30 (42.9)

0.915

18 (47.4)

26 (40.6)

0.506

13 (39.4)

34 (44.7)

0.605

36 (50.0)

11 (29.7)

0.043

 present (n=66)

23 (56.1)

40 (57.1)

20 (52.6)

38 (59.4)

20 (60.6)

42 (55.3)

36 (50.0)

26 (70.3)

Perineural invasion

            

 absent (n=51)

17 (41.5)

32 (45.1)

0.711

16 (41.0)

30 (46.9)

0.562

15 (45.5)

34 (44.2)

0.900

36 (50.0)

12 (32.4)

0.080

 present (n=68)

24 (58.5)

39 (54.9)

 

23 (59.0)

34 (53.1)

 

18 (54.5)

43 (55.8)

 

36 (50.0)

25 (67.6)

 

Tumour site

            

 Proximal bile duct (n=5)

3 (7.3)

1 (1.4)

0.251

1 (2.6)

3 (4.7)

0.418

3 (9.1)

1 (1.3)

0.074

4 (5.6)

0 (0.0)

0.288

 Distal bile duct (n=65)

22 (53.7)

38 (53.5)

24 (61.5)

31 (48.4)

19 (57.6)

39 (50.6)

39 (54.2)

19 (51.4)

 Ampullary (n=50)

16 (39.0)

32 (45.1)

14 (35.9)

30 (46.9)

11 (33.3)

37 (48.1)

29 (40.3)

18 (48.6)

  1. The frequency of observed clinicopathological variables is noted next to the variable subgroup; in some instances data was not available, 2 cases for patient age, 2 cases for tumour size: 1 case for tumour stage, 7 cases for N stage, 2 cases for vascular invasion, and 1 case for perineural invasion. The P values are resultant from Pearson Chi Square test of association (χ2) or Fisher’s Exact test in a 2×2 table if a cell count was less than 5 (indicated by *). Significant P values are indicated by bold font.
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BMC Cancer

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