Figure 4
Histological examination of mice treated with MV-NIS. Representative IHC of a mouse brain after staining with an anti-MV nucleoprotein antibody A. 7 days, B. 14 days and C. 21 days following intratumoral injection with 2 × 105 TCID50 MV-NIS. D. IHC of a tumor-free mouse brain with the same antibody, showing sparse off-target infection of cortical neurons. E. H&E staining of a spinal cord section from a control mouse in the disseminated medulloblastoma survival study showing extensive tumor infiltration. F. A spinal cord section from a mouse treated with MV-NIS + 131I. No evidence of tumor could be found in the spinal canals of five of six total animals in this treatment group.