Figure 1

MV-NIS induces syncytia formation and cell death in medulloblastoma cell lines. A. UW426 and D283med medulloblastoma cell lines were infected with MV-NIS at MOIs of 0.01, 0.1 and 1 and then monitored for the appearance of syncytia formation over the next three days. The photographs shown here were taken at 100X magnification after 48 hours of infection. B-C. In vitro kill curves for UW426 and D283med infected with MV-NIS or MV-GFP. Viability was determined by trypan blue exclusion, and each sample was run in triplicate. The number of viable cells were averaged and expressed as a percentage of an uninfected control for each corresponding timepoint. Error bars represent one standard deviation.