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Table 2 Median expression levels of the six selected miRNAs and associations with clinicopathological data

From: Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer

 

Number (percent)

miR-21

miR-31

miR-92a

miR-101

miR-106a

miR-145

Gender

       

 Female

81 (42)

7.78

0.07

1.64

0.02

1.16

0.43

 Male

112 (58)

7.53

0.03

2.12

0.02

0.93

0.48

 p-value

 

0.45

0.14

0.52

0.78

0.43

0.99

TNM

       

 I

35 (18)

5.22

0.02

2.41

0.02

1.24

0.34

 II

97 (50)

7.67

0.06

2.09

0.02

1.10

0.48

 III

61 (32)

7.78

0.07

1.59

0.02

0.85

0.51

 p-value

 

0.23

0.02

0.80

0.86

0.54

0.30

pT

       

 1

4 (2)

7.90

0.02

2.51

0.02

1.16

0.36

 2

36 (19)

5.15

0.02

2.45

0.02

1.26

0.36

 3

133 (69)

7.67

0.05

1.74

0.02

0.88

0.46

 4

20 (10)

8.50

0.14

2.58

0.02

1.33

0.58

 p-value

 

0.37

0.004

0.61

0.76

0.52

0.70

pN

       

 0

132 (68)

7.53

0.04

2.12

0.02

1.15

0.44

 1

39 (20)

7.67

0.05

1.73

0.02

0.89

0.46

 2

22 (11)

8.47

0.09

1.39

0.02

0.82

0.59

 p-value

 

0.82

0.31

0.60

0.95

0.54

0.63

Differentiation

       

 Well

6 (3)

3.58

0.02

1.09

0.01

0.38

0.24

 Intermediate

167 (87)

7.67

0.04

2.14

0.02

1.16

0.45

 Poor

20 (10)

6.83

0.20

0.95

0.02

0.70

0.69

 p-value

 

0.28

0.001

0.003

0.33

0.01

0.12

Tumor localization

       

 Colon

129 (67)

7.52

0.07

1.62

0.02

0.87

0.43

 Rectum

64 (33)

7.77

0.02

2.58

0.02

1.27

0.67

 p-value

 

0.50

0.02

0.05

0.32

0.05

0.08

Lymphocyte infiltration

      

 High

26 (14)

7.93

0.09

1.96

0.02

0.88

0.63

 Intermediate

125 (65)

7.78

0.03

2.14

0.02

1.01

0.51

 Low

40 (21)

6.91

0.08

1.46

0.02

1.04

0.33

 p-value

 

0.47

0.19

0.49

0.82

0.37

0.14

Vascular invasion

       

 Present

38 (20)

7.73

0.07

1.54

0.02

1.17

0.59

 Absent

155 (80)

7.36

0.04

2.01

0.02

0.98

0.43

 p-value

 

0.30

0.23

0.43

0.27

0.94

0.05

Perineural invasion

       

 Present

16 (8)

8.60

0.16

1.68

0.02

1.05

0.35

 Absent

177 (92)

7.54

0.04

1.95

0.02

0.98

0.48

 p-value

 

0.42

0.43

0.60

0.29

0.83

0.49

Perinodal growth*

       

 Present

38 (62)

8.09

0.11

1.46

0.02

0.81

0.52

 Absent

23 (38)

7.36

0.03

2.01

0.02

1.10

0.36

 p-value

 

0.77

0.36

0.30

1.00

0.18

0.49

  1. *Associations between miRNA expression and clinicopathological variables were explored using Mann–Whitney or Kruskal-Wallis test as appropriate; p-values are given in italic. Total number of patients included in the analyses was 193, median age was 73 years.
  2. ** Perinodal growth was only assessed in the lymph node positive patients.
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BMC Cancer

ISSN: 1471-2407

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