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Table 4 Treatment outcomes

From: Influence of oral glutamine supplementation on survival outcomes of patients treated with concurrent chemoradiotherapy for locally advanced non-small cell lung cancer

Characteristic

Glutamine (+)

Glutamine (−)

P-value

 

(N=56)

(N=48)

 

Maximum grade ARIE (N; %)

   

0–1

40 (71.4)

21 (43.7)

0.02

2

37.0

34.2

 

3

27.8

22.8

 

4 - 5

0 (0)

0 (0)

 

Grade 2–3 ARIE onset (days)

   

Median

24.5

16.4

0.001

Range

(17 – 32)

(9–23)

 

Treatment delay (N; %)

4 (7.1)

10 (20.8%)

0.04

Hospitalization

2 (3.6)

3 (6.3)

0.14

Weight change (N; %)

   

No change or gain

31 (55.4)

13 (27.1)

0.002

Loss

25 (44.6)

35 (72.9)

 

Weight change (kg)

   

Median

2.6

−3.3

< 0.001

Range

(−3.1 to 7.6)

(−9.7 to 2.3)

 

Weight change (%)

   

Median

3.94

−4.91

< 0.001

Range

(−4.7 to 11.5)

(−14.4 to 3.4)

 

LET (maximum grade)

   

2

2 (3.6)

3 (6.3)

0.06

3

0 (0)

3 (6.3)

 

4 - 5

0 (0)

0 (0)

 
  1. Abbreviations: ARIE: Acute radiation-induced esophagitis; LET: Late esophageal toxicity.