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Table 1 Top 13 genes correlating with HER2/ERBB2 expression

From: Identification of PADI2 as a potential breast cancer biomarker and therapeutic target

Symbol

Description

rho

PGAP3

Post-GPI attachment to proteins 3 (PERLD1)

0.941

CREB3L3

CAMP responsive element binding protein 3-like 3

0.927

C2orf54

Chromosome 2 open reading frame 54

0.860

EFCAB4A

EF-hand calcium binding domain 4A

0.857

ARHGAP8

Rho GTPase activating protein 8

0.852

GRB7

Growth factor receptor-bound protein 7

0.851

TMEM210

Transmembrane protein 210

0.849

CLDN4

Claudin 4

0.847

MB

Myoglobin

0.846

ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

0.842

TRIM3

Tripartite motif containing 3

0.839

PRSS8

Protease, serine, 8

0.829

PADI2

Peptidylarginine deiminase, type II

0.828

  1. Genes identified by RNA-seq to be upregulated in HER2/ERBB2+ breast cancers were tested for correlation (Spearman’s rho) and the top 13 genes are ranked from top to bottom, with PADI2 exhibiting the 13th strongest correlation with HER2/ERBB2 overexpression.