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Table 1 Association of PIK3CA mutations and amplification with clinicopathologic variables

From: Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer

Variable PIK3CA mutations (n = 113) PIK3CA amplification (n = 131)
  Yes No P Yes No P
No.of patients 8 105   88 43  
Gender       
   Male 5 82 0.57 68 34 0.82
   Female 3 23   20 9  
Age, years       
   Mean 55.5 59.1 0.47 58.6 61.4 0.25
   SD 19.8 12.7   13.3 12.1  
Tumor localization       
   gastric cardia 0 26 0.98 23 12 0.66
   gastric body 5 24   22 12  
   gastric antrum 3 55   43 19  
Tumor size (cm3)       
   ≤ 3 3 35 0.68 29 14 0.88
   3-5 3 35   32 15  
   > 5 2 35   27 14  
Differentiation       
   well/moderate 1 44 0.21 33 23 0.08
   poor/undifferentiation 7 61   55 20  
Tumor invasion       
   T1 2 14 0.96 9 5 0.59
   T2 0 17   15 8  
   T3 6 72   62 30  
   T4 0 2   2 0  
TNM stage       
   I 2 27 0.91 20 10 0.86
   II 1 14   15 6  
   III 5 58   49 25  
   IV 0 6   4 2  
Residual tumor       
   Yes 1 12 1.00 12 2 0.10
   No 7 93   76 41  
Lymph node metastasis (LNM)       
   Yes 5 65 1.00 57 24 0.32
   No 3 40   31 19  
No. of LNM       
   N0 3 40 0.63 31 19 0.20
   N1 (1-6) 4 36   32 16  
   N2 (7-15) 1 23   20 7  
   N3 (≥ 16) 0 6   5 1  
Survival status       
   Dead 3 53 0.73 51 15 0.01*
   Alive 5 52   37 28  
  1. * Significant at P < 0.05