Table 1 Association of PIK3CA mutations and amplification with clinicopathologic variables

From: Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer

Variable	PIK3CA mutations (n = 113)			PIK3CA amplification (n = 131)
	Yes	No	P	Yes	No	P
No.of patients	8	105		88	43
Gender
Male	5	82	0.57	68	34	0.82
Female	3	23		20	9
Age, years
Mean	55.5	59.1	0.47	58.6	61.4	0.25
SD	19.8	12.7		13.3	12.1
Tumor localization
gastric cardia	0	26	0.98	23	12	0.66
gastric body	5	24		22	12
gastric antrum	3	55		43	19
Tumor size (cm³)
≤ 3	3	35	0.68	29	14	0.88
3-5	3	35		32	15
> 5	2	35		27	14
Differentiation
well/moderate	1	44	0.21	33	23	0.08
poor/undifferentiation	7	61		55	20
Tumor invasion
T1	2	14	0.96	9	5	0.59
T2	0	17		15	8
T3	6	72		62	30
T4	0	2		2	0
TNM stage
I	2	27	0.91	20	10	0.86
II	1	14		15	6
III	5	58		49	25
IV	0	6		4	2
Residual tumor
Yes	1	12	1.00	12	2	0.10
No	7	93		76	41
Lymph node metastasis (LNM)
Yes	5	65	1.00	57	24	0.32
No	3	40		31	19
No. of LNM
N0	3	40	0.63	31	19	0.20
N1 (1-6)	4	36		32	16
N2 (7-15)	1	23		20	7
N3 (≥ 16)	0	6		5	1
Survival status
Dead	3	53	0.73	51	15	0.01*
Alive	5	52		37	28

* Significant at P < 0.05

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