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Table 4 Kaplan-Meier analyses of all parameters with median survival and 95% confidence interval before and 24 h after SIRT

From: Predictive and prognostic value of circulating nucleosomes and serum biomarkers in patients with metastasized colorectal cancer undergoing Selective Internal Radiation Therapy

Biomarker Time Quartile 1 Quartile 2 Quartile 3 Quartile 4 p-value
   Median survival [months] 95% Confi. Interval Median survival [months] 95% Confi. Interval Median survival [months] 95% Confi. Interval Median survival [months] 95% Confi. Interval Log-rank
Nucleosomes [ng/mL] 0 h < 83 83-190 191-415 > 415 0.1275
   17.3 1.5 - 8.2 4.6 - 13.8 3.2-23.8 6.0 1.5-15.4  
  24 h < 384 384-751 752-1232 > 1232 0.0004
   23.8 4.9-23.8 8.0 2.5 - 13.8 4.0-20.6 5.1 1.4-6.1  
CYFRA 21-1
[ng/mL]
0 h < 5.3 5.3-10.0 10.0-32 > 32.8 < .0001
   20.6 8.2 -   4.9 - 7.0 2.8-18.8 3.1 1.4-5.1  
  24 h < 13 13-28 29-74 > 74 0.0009
   20.6 8.2-23.8 6.3 3.4 - 6.2 3.1 - 4.6 1.4-15.0  
CEA
[U/L]
0 h < 55 55-320 321-1041 > 1041 0.0002
   20.6 3.1 - 19.6 5.6 - 8.3 4.2-18.8 3.1 1.4-6.1  
  24 h < 85 85-351 352-982 > 982 0.0002
   20.6 8.2-23.8 19.6 4.2 - 5.5 2.5-8.8 4.9 1.5-15.0  
CA 19-9
[U/L]
0 h < 10 10-40 41-285 > 285 0.0006
   15.0 3.1 - 23.8 8.2 - 6.6 2.8 - 4.9 1.4-6.2  
  24 h < 10 10-48 49-285 > 285 0.0096
   15.4 3.1 - 17.8 4.2-23.8 6.6 2.8 - 5.5 1.4-11.0  
CRP
[mg/dL]
0 h < 0.5 0.5-1.3 1.4-8.3 > 8.3 < .0001
   23.8 19.6 - 14.4 3.4 - 6.8 4.4-15.0 3.1 1.4-5.1  
  24 h < 0.7 0.7-1.3 1.4-6.4 > 6.4 < .0001
   23.8 11.0-23.8   4.7 - 8.8 5.8-15.4 3.0 1.4-5.1  
LDH
[U/L]
0 h < 299 299-393 394-604 > 604 < .0001
   20.6 8.2 - 15.4 4.7 - 8.8 1.5-23.8 3.2 1.5-5.0  
  24 h < 336 336-486 487-878 > 878 0.0002
   23.8 8.2 - 11.0 4.4 - 6.8 4.6-16.8 2.8 1.4-15.0  
AST
[U/L]
0 h < 35 35-52 53-66 > 66 < .0001
   20.6 15.0 - 13.8 5.0 - 7.3 4.6-15.0 3.0 1.4-4.2  
  24 h < 48 48-74 75-135 > 135 0.0004
    11.0 - 6.3 4.6-19.6 5.6 2.8-15.4 3.4 1.5-15.0  
ALT
[U/L]
0 h < 26 26-34 35-50 > 50 0.0773
   18.8 5.2 - 7.8 3.1 - 13.8 5.1-15.4 3.8 1.5-23.8  
  24 h < 30 30-46 47-64 > 64 0.0824
   20.6 5.2 - 5.5 4.4-15.0 15.0 2.6-19.6 4.1 1.5 -  
CHE
[kU/L]
0 h < 5.8 5.8-7.3 7.4-8.4 > 8.4 0.0013
   5.1 1.5-6.2 5.9 2.8 - 8.2 4.0-19.6 28.8 11.0-23.8  
  24 h < 5.1 5.1-6.3 6.4-7.6 > 7.6 0.0002
   4.7 1.4-6.8 5.4 2.5-20.6 23.8 4.4 - 18.8 8.2 -  
GGT
[U/L]
0 h < 110 110-183 184-282 > 282 0.0034
   16.7 5.9 - 18.8 4.4-20.6 11.0 2.8-15.4 4.4 2.5-7.8  
  24 h < 94 94-165 166-274 > 274 0.0101
   17.3 6.8 - 12.5 4.4-20.6 15.0 2.8 - 4.8 2.5-7.8  
AP
[U/L]
0 h < 114 114 - 160 161 - 321 > 321 < .0001
   20.6 8.2 - 18.8 4.6 - 23.8 6.2 3.2 - 4.2 1.5 - 5.5  
  24 h < 98 98 - 148 149 - 265 > 265 < .0001
   23.8 8.2 - 13.8 4.6 - 19.6 7.8 3.4 - 18.8 3.7 4.1 - 6.2  
Bilirubin [mg/dL] 0 h < 0.5 0.5 - 0.7 0.8 - 1.2 > 1.2 0.2393
   14.4 4.4 - 11.0 2.8 - 18.8 5.1 - 4.4 1.5 - 15.0  
  24 h < 0.8 0.8 - 1.0 1.1 - 1.8 > 1.8 0.3335
   10.3 4.0 - 19.6 15.4 4.6 - 5.9 2.5 - 8.2 1.5 - 23.8  
Amylase
[U/L]
0 h < 44 44 - 58 59 - 75 > 75 0.0102
   5.2 1.4 - 18.8 7.5 3.2 - 19.6 17.4 2.5 - 23.8   5.8 -  
  24 h < 35 35 - 44 44 - 63 > 63 0.0030
   5.2 3.2 - 15.4 6.2 3.1 - 15.0 2.8 - 20.6 1.5 -  
Lipase
[U/L]
0 h < 13 13 - 26 27 - 38 > 38 0.5314
   5.7 1.5 - 18.8 2.8 - 8.8 4.0 - 13.0 3.4 - 19.6  
  24 h < 10 10- 18 18 - 28 > 28 0.6226