Table 4 Kaplan-Meier analyses of all parameters with median survival and 95% confidence interval before and 24 h after SIRT

Nucleosomes [ng/mL]

0 h

< 83

83-190

191-415

> 415

0.1275

17.3

1.5 -

8.2

4.6 -

13.8

3.2-23.8

6.0

1.5-15.4

24 h

< 384

384-751

752-1232

> 1232

0.0004

23.8

4.9-23.8

8.0

2.5 -

13.8

4.0-20.6

5.1

1.4-6.1

CYFRA 21-1

[ng/mL]

0 h

< 5.3

5.3-10.0

10.0-32

> 32.8

< .0001

20.6

8.2 -

4.9 -

7.0

2.8-18.8

3.1

1.4-5.1

24 h

< 13

13-28

29-74

> 74

0.0009

20.6

8.2-23.8

6.3

3.4 -

6.2

3.1 -

4.6

1.4-15.0

CEA

[U/L]

0 h

< 55

55-320

321-1041

> 1041

0.0002

20.6

3.1 -

19.6

5.6 -

8.3

4.2-18.8

3.1

1.4-6.1

24 h

< 85

85-351

352-982

> 982

0.0002

20.6

8.2-23.8

19.6

4.2 -

5.5

2.5-8.8

4.9

1.5-15.0

CA 19-9

[U/L]

0 h

< 10

10-40

41-285

> 285

0.0006

15.0

3.1 -

23.8

8.2 -

6.6

2.8 -

4.9

1.4-6.2

24 h

< 10

10-48

49-285

> 285

0.0096

15.4

3.1 -

17.8

4.2-23.8

6.6

2.8 -

5.5

1.4-11.0

CRP

[mg/dL]

0 h

< 0.5

0.5-1.3

1.4-8.3

> 8.3

< .0001

23.8

19.6 -

14.4

3.4 -

6.8

4.4-15.0

3.1

1.4-5.1

24 h

< 0.7

0.7-1.3

1.4-6.4

> 6.4

< .0001

23.8

11.0-23.8

4.7 -

8.8

5.8-15.4

3.0

1.4-5.1

LDH

[U/L]

0 h

< 299

299-393

394-604

> 604

< .0001

20.6

8.2 -

15.4

4.7 -

8.8

1.5-23.8

3.2

1.5-5.0

24 h

< 336

336-486

487-878

> 878

0.0002

23.8

8.2 -

11.0

4.4 -

6.8

4.6-16.8

2.8

1.4-15.0

AST

[U/L]

0 h

< 35

35-52

53-66

> 66

< .0001

20.6

15.0 -

13.8

5.0 -

7.3

4.6-15.0

3.0

1.4-4.2

24 h

< 48

48-74

75-135

> 135

0.0004

11.0 -

6.3

4.6-19.6

5.6

2.8-15.4

3.4

1.5-15.0

ALT

[U/L]

0 h

< 26

26-34

35-50

> 50

0.0773

18.8

5.2 -

7.8

3.1 -

13.8

5.1-15.4

3.8

1.5-23.8

24 h

< 30

30-46

47-64

> 64

0.0824

20.6

5.2 -

5.5

4.4-15.0

15.0

2.6-19.6

4.1

1.5 -

CHE

[kU/L]

0 h

< 5.8

5.8-7.3

7.4-8.4

> 8.4

0.0013

5.1

1.5-6.2

5.9

2.8 -

8.2

4.0-19.6

28.8

11.0-23.8

24 h

< 5.1

5.1-6.3

6.4-7.6

> 7.6

0.0002

4.7

1.4-6.8

5.4

2.5-20.6

23.8

4.4 -

18.8

8.2 -

GGT

[U/L]

0 h

< 110

110-183

184-282

> 282

0.0034

16.7

5.9 -

18.8

4.4-20.6

11.0

2.8-15.4

4.4

2.5-7.8

24 h

< 94

94-165

166-274

> 274

0.0101

17.3

6.8 -

12.5

4.4-20.6

15.0

2.8 -

4.8

2.5-7.8

AP

[U/L]

0 h

< 114

114 - 160

161 - 321

> 321

< .0001

20.6

8.2 -

18.8

4.6 - 23.8

6.2

3.2 -

4.2

1.5 - 5.5

24 h

< 98

98 - 148

149 - 265

> 265

< .0001

23.8

8.2 -

13.8

4.6 - 19.6

7.8

3.4 - 18.8

3.7

4.1 - 6.2

Bilirubin [mg/dL]

0 h

< 0.5

0.5 - 0.7

0.8 - 1.2

> 1.2

0.2393

14.4

4.4 -

11.0

2.8 -

18.8

5.1 -

4.4

1.5 - 15.0

24 h

< 0.8

0.8 - 1.0

1.1 - 1.8

> 1.8

0.3335

10.3

4.0 - 19.6

15.4

4.6 -

5.9

2.5 -

8.2

1.5 - 23.8

Amylase

[U/L]

0 h

< 44

44 - 58

59 - 75

> 75

0.0102

5.2

1.4 - 18.8

7.5

3.2 - 19.6

17.4

2.5 - 23.8

5.8 -

24 h

< 35

35 - 44

44 - 63

> 63

0.0030

5.2

3.2 - 15.4

6.2

3.1 -

15.0

2.8 -

20.6

1.5 -

Lipase

[U/L]

0 h

< 13

13 - 26

27 - 38

> 38

0.5314

5.7

1.5 -

18.8

2.8 -

8.8

4.0 -

13.0

3.4 - 19.6

24 h

< 10

10- 18

18 - 28

> 28

0.6226