Predictive and prognostic value of circulating nucleosomes and serum biomarkers in patients with metastasized colorectal cancer undergoing Selective Internal Radiation Therapy

Table 2 Levels of biomarkers before, 3, 6, 24 and 48 h after application of SIRT

	Reference value (95th perc. of healthy)	0 hours	3 hours	6 hours	24 hours	48 hours
		Median	Median	Median	Median	Median
		Range	Range	Range	Range	Range
Nucleo-somes [ng/mL]		190.5	197.6	237.4	758.5	596.0
	< 36	5.0-1624	34.8-2501	40.7-2064	21.7-4334	51.7-2547
CYFRA 21-1 [ng/mL]		10.9	9.3	8.8	28.6	27.5
	< 2.2	0.8-246.0	0.9-240.0	1.1-230.0	1.0-811.0	1.5-638.0
CEA [ng/mL]		330.0	343.5	356.5	351.0	433.0
	< 3.4	2.0-31620	1.9-33010	1.9-16980	1.6-36120	1.6-37550
CA 19-9 [U/mL]		40.0	41.6	49.7	48.7	56.4
	< 37	2.4-11530	2.3-24400	2.2-8748	2.4-18550	2.3-17000
LDH [U/L]		407.0			486.5	585.0
	< 250	178.0-3068			143.0-2923	142.0-3585
CRP [mg/dL]		1.3			1.3	4.6
	< 0.5	0.1-20.3			1.3-21.8	0.1-16.3
CHE [kU/L]		7.3			6.3	5.9
	5.0-13.3	2.8-11.1			2.8-11.1	5.9-10.5
AST [U/L]		52.0			74.5	68.5
	< 33	24.0-190.0			15.0-339.0	19.0-317.0
ALT [U/L]		34.5			46.0	48.5
	< 35	15.0-268.0			14.0-178.0	13.0-136.0
Bilirubin [mg/dL]		0.7			1.0	1.2
	< 1.0	0.3-1.9			0.4-2.2	0.4-2.8
AP [U/L]		160.0			148.0	156.0
	< 135	81.0-742.0			63.0-655.0	61.0-630.0
GGT [U/L]		183.5			165.5	168.5
	< 38	33.0-712.0			31.0-577.0	31.0-653.0
Amylase [U/L]		58.0			44.0	46.5
	< 100	20.0-136.0			20.0-429.0	20.0-519.0
Lipase [U/L]		26.0			18.0	20.0
	< 60	3.0-263.0			3.0-585.0	3.0-495.0