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Table 2 Levels of biomarkers before, 3, 6, 24 and 48 h after application of SIRT

From: Predictive and prognostic value of circulating nucleosomes and serum biomarkers in patients with metastasized colorectal cancer undergoing Selective Internal Radiation Therapy

 

Reference value (95th perc. of healthy)

0 hours

3 hours

6 hours

24 hours

48 hours

  

Median

Median

Median

Median

Median

  

Range

Range

Range

Range

Range

Nucleo-somes [ng/mL]

 

190.5

197.6

237.4

758.5

596.0

 

< 36

5.0-1624

34.8-2501

40.7-2064

21.7-4334

51.7-2547

CYFRA 21-1

[ng/mL]

 

10.9

9.3

8.8

28.6

27.5

 

< 2.2

0.8-246.0

0.9-240.0

1.1-230.0

1.0-811.0

1.5-638.0

CEA

[ng/mL]

 

330.0

343.5

356.5

351.0

433.0

 

< 3.4

2.0-31620

1.9-33010

1.9-16980

1.6-36120

1.6-37550

CA 19-9 [U/mL]

 

40.0

41.6

49.7

48.7

56.4

 

< 37

2.4-11530

2.3-24400

2.2-8748

2.4-18550

2.3-17000

LDH

[U/L]

 

407.0

  

486.5

585.0

 

< 250

178.0-3068

  

143.0-2923

142.0-3585

CRP

[mg/dL]

 

1.3

  

1.3

4.6

 

< 0.5

0.1-20.3

  

1.3-21.8

0.1-16.3

CHE

[kU/L]

 

7.3

  

6.3

5.9

 

5.0-13.3

2.8-11.1

  

2.8-11.1

5.9-10.5

AST

[U/L]

 

52.0

  

74.5

68.5

 

< 33

24.0-190.0

  

15.0-339.0

19.0-317.0

ALT

[U/L]

 

34.5

  

46.0

48.5

 

< 35

15.0-268.0

  

14.0-178.0

13.0-136.0

Bilirubin

[mg/dL]

 

0.7

  

1.0

1.2

 

< 1.0

0.3-1.9

  

0.4-2.2

0.4-2.8

AP

[U/L]

 

160.0

  

148.0

156.0

 

< 135

81.0-742.0

  

63.0-655.0

61.0-630.0

GGT

[U/L]

 

183.5

  

165.5

168.5

 

< 38

33.0-712.0

  

31.0-577.0

31.0-653.0

Amylase

[U/L]

 

58.0

  

44.0

46.5

 

< 100

20.0-136.0

  

20.0-429.0

20.0-519.0

Lipase

[U/L]

 

26.0

  

18.0

20.0

 

< 60

3.0-263.0

  

3.0-585.0

3.0-495.0