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Table 6 Hypofractionated radiotherapy studies

From: Health-related quality of life in survivors of stage I-II breast cancer: randomized trial of post-operative conventional radiotherapy and hypofractionated tomotherapy

Trial Period n Hypofraction schedule SIB Mastectomy Regional nodes IMRT/ IGRT Chemotherapy Cosmesis HRQOL
UK Start A [17, 19] 1998-2002 2236 3 Gy x 13 F/ 5 weeks No Yes Yes NS Yes Yes Yes
3.2 Gy x 13 F/ 5 weeks
UK Start B [18, 19] 1999-2001 2215 2.67 Gy x 15 F/ 3 weeks No Yes Yes NS Yes Yes Yes
Ontario [15] 1993-1996 1234 2.66 Gy x 16 F/ 3 weeks No No No NS Yes Yes No
Egypt NCI [20] 2002-2003 30 2.66 Gy x 16 F/ 3 weeks No No No NS No Yes No
UK FAST [21] 2004-2007 915 5.7 Gy x 5 F/ 5 weeks ? No No Yes No No No
6 Gy x 5 F/ 5 weeks
Hopital Necker (*) [22] 1982-1984 230 5.75 Gy x 4 F/ 17 days No Yes ? NS Yes No No
Royal Marsden Hospital [23] 1986-1998 1410 3 Gy x 13 F/ 5 weeks 3.3 Gy x 13 F/ 5 weeks No No Yes NS No No No
Lahore [24] 1998-2004 300 5.4 Gy x 5 F/ 1 week 3.5 Gy x 10 F/ 2 weeks No Yes Yes NS Yes No No
2.66 Gy x 15 F/ 3 weeks
UZ Brussel 2007-2011 121 2.8 Gy [SIB 3.4 Gy]x15 F/ 3 weeks Yes Yes Yes Yes Yes No Yes
  1. NS: not stated.