Skip to main content

Table 5 Univariate analysis of survival (n = 41)

From: Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors

  Patients Mean survival (months) Median survival (months) p-Value (log-rank)
Overall survival 41 4.5 3  
Characteristics     
Gender     0.386
   Male 33 4.7 3  
   Female 8 3.6 2.5  
Age (years)     
   < 50 23 4.4 3 0.893
   ≥ 50 18 4.6 3.5  
Primary tumor     0.156
   Controlled 16 5.8 3.5  
   Uncontrolled 25 3.7 3  
Etiology     
   Hepatitis B 30 4.1 3 0.308
   None 11 5.6 3  
Child-Pugh's classification     
   A 27 4.9 3.5 0.364
   B/C 14 3.8 3  
APF (ng/ml)     
   < 400 15 3.4 2 0.218
   ≥ 400 26 5.1 3.5  
CEA (ng/ml)     
   < 5 26 4.8 3 0.725
   ≥ 5 5 3.9 3  
CA199 (u/ml)     0.455
   < 35 22 3.9 3  
   ≥ 35 10 5.6 3  
Extracranial metastasis     
   Yes 33 5.2 3.5 < 0.0001
   No 8 1.4 1  
Lung metastasis     
   Yes 31 5.4 4 0.001
   No 10 1.7 1.7  
Bone metastasis     
   Yes 9 5.8 4 0.272
   No 32 4.1 2.5  
Brain hemorrhage     
   Yes 19 4.1 1.5 0.495
   No 22 4.9 3.5  
Interval (months)     
   < 12 16 3.5 3 0.272
   ≥ 12 25 5.1 3.5  
Number of brain lesions     
   Single 24 4.2 3 0.572
   Multiple 17 4.9 3.5  
Location     
   Supratentorial 29 5 3 0.293
   Infratentorial or combinations 12 3.4 1.5  
Treatment     
   Surgery or WBRT and/or SRS 18 6.8 4.5 0.001
   Steroid only 23 2.7 1.5  
RPA class     
   I or II 25 6.4 6 < 0.0001
   III 16 1.6 1