Table 2 Characteristics of brain metastasis (n = 41)

Median age at diagnosis of HCC (range), years

48.5(25-82)

Median interval between diagnosis of BM from HCC (range), months

15(0-120)

Age at diagnosis of HCC (years)

   < 50

23(56.1%)

   ≥ 50

18(43.9%)

Gender

   Female

8(19.5%)

   Male

33(80.5%)

Site of extracranial metastases

   Lung

31(75.6%)

   Bone

9(22%)

   Adrenal gland

4(9.8%)

   other sites

3(7.3%)

Radiological data

   CT

22(53.7%)

   MRI

19(46.3%)

Location of brain lesions

   Supratentorial

29(70.7%)

   Infratentorial

7(17.1%)

   Combinations

5(12.2%)

APF (ng/ml)

   < 400

15(36.6%)

   ≥ 400

26(63.4%)

CEA (ng/ml)

   < 5

26(63.4%)

   ≥ 5

5(12.2%)

   Unkown

10(24.4%)

CA199 (u/ml)

   < 35

22(53.7%)

   ≥ 35

10(24.4%)

   Unkown

9(22%)

Symptom

   Headache

17(41.5%)

   Motor weakness

14(34.1%)

   Nausea

12(29.3%)

   Mental change

6(14.6%)

   Seizure

4(9.8%)

   Visual disturbance

4(9.8%)

   Cerebellar dysfunction

3(7.3%)

   Aphasia

2(4.9%)

   None

1(2.4%)

Interval between diagnosis of HCC and BM (months)

   < 12

25(61%)

   ≥ 12

16(39%)

Number of brain lesions

   1

24(58.5%)

   2

4(9.8%)

   ≥ 3

13(31.7%)

Brain hemorrhage

   Yes

19(46.3%)

   No

22(53.7%)

KPS

   90-100

6(14.6%)

   80-89

7(17.1%)

   70-79

12(29.3%)

   60-69

9(22%)

   < 60

7(17.1%)

RPA class

   I

1(2.4%)

   II

24(58.5%)

   III

16(39.0%)