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Table 2 Characteristics of brain metastasis (n = 41)

From: Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors

Characteristic No.(%)
Median age at diagnosis of HCC (range), years 48.5(25-82)
Median interval between diagnosis of BM from HCC (range), months 15(0-120)
Age at diagnosis of HCC (years)  
   < 50 23(56.1%)
   ≥ 50 18(43.9%)
Gender  
   Female 8(19.5%)
   Male 33(80.5%)
Site of extracranial metastases  
   Lung 31(75.6%)
   Bone 9(22%)
   Adrenal gland 4(9.8%)
   other sites 3(7.3%)
Radiological data  
   CT 22(53.7%)
   MRI 19(46.3%)
Location of brain lesions  
   Supratentorial 29(70.7%)
   Infratentorial 7(17.1%)
   Combinations 5(12.2%)
APF (ng/ml)  
   < 400 15(36.6%)
   ≥ 400 26(63.4%)
CEA (ng/ml)  
   < 5 26(63.4%)
   ≥ 5 5(12.2%)
   Unkown 10(24.4%)
CA199 (u/ml)  
   < 35 22(53.7%)
   ≥ 35 10(24.4%)
   Unkown 9(22%)
Symptom  
   Headache 17(41.5%)
   Motor weakness 14(34.1%)
   Nausea 12(29.3%)
   Mental change 6(14.6%)
   Seizure 4(9.8%)
   Visual disturbance 4(9.8%)
   Cerebellar dysfunction 3(7.3%)
   Aphasia 2(4.9%)
   None 1(2.4%)
Interval between diagnosis of HCC and BM (months)  
   < 12 25(61%)
   ≥ 12 16(39%)
Number of brain lesions  
   1 24(58.5%)
   2 4(9.8%)
   ≥ 3 13(31.7%)
Brain hemorrhage  
   Yes 19(46.3%)
   No 22(53.7%)
KPS  
   90-100 6(14.6%)
   80-89 7(17.1%)
   70-79 12(29.3%)
   60-69 9(22%)
   < 60 7(17.1%)
RPA class  
   I 1(2.4%)
   II 24(58.5%)
   III 16(39.0%)