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Table 1 Scoring results of the immunohistochemical staining in central chondrosarcoma

From: BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors

Diagnosis

pSmad1/5/8

pSmad2

Endoglin / CD105

Higha

%

p-valueb

Higha

%

p-valueb

Higha

%

p-valueb

total

13 / 25

52.0

 

15 / 24

62.5

 

11 / 26

42.3

 

CCS I

2 / 9

22.2

 

4 / 10

40.0

 

1 / 9

11.1

 

CCS II

7 / 10

70.0

 

6 / 8

75.0

 

7 / 10

70.0

 

CCS III

4 / 6

66.7

 

5 / 6

83.3

 

3 / 6

50.0

 

high grade c

11 / 16

68.8

0.04

11 / 14

78.6

0.09

10 / 16

62.5

0.03

  1. a: number of tumor samples with high expression defined as showing a total sum score higher than 3.
  2. b: p-value of the Fisher’s exact test for the comparison of the corresponding sample group with CCS I. Significant p-values are shown in bold.
  3. c: high grade: grade II and grade III.