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Table 1 Scoring results of the immunohistochemical staining in central chondrosarcoma

From: BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors

Diagnosis pSmad1/5/8 pSmad2 Endoglin / CD105
Higha % p-valueb Higha % p-valueb Higha % p-valueb
total 13 / 25 52.0   15 / 24 62.5   11 / 26 42.3  
CCS I 2 / 9 22.2   4 / 10 40.0   1 / 9 11.1  
CCS II 7 / 10 70.0   6 / 8 75.0   7 / 10 70.0  
CCS III 4 / 6 66.7   5 / 6 83.3   3 / 6 50.0  
high grade c 11 / 16 68.8 0.04 11 / 14 78.6 0.09 10 / 16 62.5 0.03
  1. a: number of tumor samples with high expression defined as showing a total sum score higher than 3.
  2. b: p-value of the Fisher’s exact test for the comparison of the corresponding sample group with CCS I. Significant p-values are shown in bold.
  3. c: high grade: grade II and grade III.