Statin use and association with colorectal cancer survival and risk: case control study with prescription data linkage

Table 2 Association between colorectal cancer and statin use among 309 cases and 294 control patients (unadjusted model) and 190 cases and 209 control patients in the adjusted model

Statin use	Unadjusted model			Adjusted model
	Cases (309)	Controls (294)	Basic OR* (95% CI)	Cases (194)	Controls (211)	Adjusted OR† (95% CI)
	Cases (309)	Controls (294)	P-value	Cases (194)	Controls (211)	P-value
No use of statins	284	250	1.0 (referent)	154	145	1.0 (referent)
≥1dispensed prescription at least 2 months pre-recruitment	25	44	0.52 (0.31, 0.89)	15	38	0.33 (0.15, 0.69)
≥1dispensed prescription at least 2 months pre-recruitment	25	44	0.016 **	15	38	0.004**
≥1dispensed prescription at least 7 months pre-recruitment	24	38	0.60 (0.35, 1.04)	14	32	0.39 (0.18, 0.85)
≥1dispensed prescription at least 7 months pre-recruitment	24	38	0.067	14	32	0.017**
≥2 dispensed prescriptions at least 2 months pre-recruitment	24	38	0.60 (0.35, 1.03)	14	32	0.42 (0.19, 0.92)
	24	38	0.064	14	32	0.030**
≥2 dispensed prescriptions at least 7 months pre-recruitment	23	34	0.65 (0.37, 1.14)	13	28	0.49 (0.22, 1.08)
			0.135			0.077

* Adjusted for matching factors (age +/−1 year), sex and region of residence). OR = Odds ratio; CI = confidence interval.
† Adjusted for matching factors ((age +/−1 year), sex and region of residence), Family history of cancer, past medical history of cancer, past medical history of bowel disease, BMI, smoking, physical activity and regular NSAID intake.
** statistically significant at p < 0.05.

ISSN: 1471-2407