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Table 5 Grade 3 and 4 adverse events associated with the induction chemotherapy

From: Phase I trial of split-dose induction docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer (TISOC-1)

Toxicity

Level 0

(%)

Level −1

(%)

All patients

(%)

N = 12

 

N = 6

 

N = 18

 

Hematologic

Neutropenia

9

(75)

1

(17)

10

(56)

Leukopenia

-

-

1

(17)

1

(6)

Anemia

1

(8)

-

-

1

(6)

Non-hematologic

Diarrhea

1

(8)

-

-

1

(6)

Dysphagia

1

(8)

-

-

1

(6)

Mucositis

4

(33)

1

(17)

5

(28)

Hyperkalemia

-

-

1

(17)

1

(6)

Hyponatremia

1

(8)

1

(17)

2

(11)

Renal failure

1

(8)

-

-

1

(6)