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Table 5 Grade 3 and 4 adverse events associated with the induction chemotherapy

From: Phase I trial of split-dose induction docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer (TISOC-1)

Toxicity Level 0 (%) Level −1 (%) All patients (%)
N = 12   N = 6   N = 18  
Hematologic
Neutropenia 9 (75) 1 (17) 10 (56)
Leukopenia - - 1 (17) 1 (6)
Anemia 1 (8) - - 1 (6)
Non-hematologic
Diarrhea 1 (8) - - 1 (6)
Dysphagia 1 (8) - - 1 (6)
Mucositis 4 (33) 1 (17) 5 (28)
Hyperkalemia - - 1 (17) 1 (6)
Hyponatremia 1 (8) 1 (17) 2 (11)
Renal failure 1 (8) - - 1 (6)